RIFATER (rifampin/isoniazid/pyrazinamide) tablets are combination tablets containing 120 mg rifampin, 50 mg isoniazid, and 300 mg pyrazinamide for use in antibacterial therapy. The tablets also contain as inactive ingredients: povidone, carboxymethylcellulose sodium, calcium stearate, sodium lauryl sulfate, sucrose, talc, acacia, titanium dioxide, kaolin, magnesium carbonate, colloidal silicon dioxide, dried aluminum hydroxide gel, ferric oxide, black iron oxide, carnauba wax, white beeswax, colophony, hard paraffin, lecithin, shellac, and propylene glycol. The RIFATER triple therapy combination was developed for dosing convenience.
Rifampin
Rifampin is a semisynthetic antibiotic derivative of rifamycin SV. Rifampin is a red-brown crystalline powder very slightly soluble in water at neutral pH, freely soluble in chloroform, soluble in ethyl acetate and methanol. Its molecular weight is 822.95 and its chemical formula is C43H5gN4Oi2. The chemical name for rifampin is either:
3 - [ [(4-methyl-1 -piperazinyl) imino] -methyl] -rifamycin; or 5,6,9,17,19,21
-hexahydroxy-23methoxy-2,4,12,16,18,20,22 heptamethyl-8-[N-(4-methyl-l-piperazinyl)formimidoyl]-2,7-(epoxypentadeca
[1,1 l,13]trienimino)naphtho[2,l-b]furan-l, 1 l(2H)-dione 21-acetate. Its structural
formula is:
Isoniazid
Isoniazid is the hydrazide of isonicotinic acid. It is a colorless or white
crystalline powder or white crystals. It is odorless and slowly affected by
exposure to air and light. It is freely soluble in water, sparingly soluble
in alcohol and slightly soluble in chloroform and in ether. Its molecular weight
is 137.14 and its chemical formula is C6H7N3O.
The chemical name for isoniazid is 4-pyridinecarboxylic acid, hydrazide and
its structural formula is:
Pyrazinamide
Pyrazinamide, the pyrazine analogue of nicotinamide, is a white, crystalline
powder, stable at room temperature, and sparingly soluble in water. The chemical
name for pyrazinamide is pyrazinecarboxamide and its molecular weight is 123.11.
Its chemical formula is C5H5N3O and its structural
formula is:
What are the possible side effects of rifampin (Rifadin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- fever, chills, body aches, flu symptoms;
- joint pain or swelling;
- easy bruising or bleeding, weakness;
- urinating less than usual or not at all; or
- nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the...
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What are the precautions when taking rifampin (Rifadin)?
Before taking rifampin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, liver problems (e.g., hepatitis), HIV infection, history of alcohol use/abuse.
This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.
Before having surgery, tell your doctor or dentist that you are using this drug.
During pregnancy, this medication should...
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Last reviewed on RxList: 12/17/2010
This monograph has been modified to include the generic and brand name in many instances.