July 29, 2016
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Rifamate Patient Information including If I Miss a Dose

What happens if I miss a dose (Rifamate)?

Take the missed dose as soon as you remember. If it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

What happens if I overdose (Rifamate)?

Seek emergency medical attention.

Symptoms of an isoniazid and rifampin overdose include nausea, vomiting, abdominal pain, tiredness, dizziness, slurring of speech, yellow skin or eyes, blurred vision, visual hallucinations, seizures, coma, and death.

What should I avoid while taking isoniazid and rifampin (Rifamate)?

Do not wear contact lenses while taking isoniazid and rifampin. Rifampin may turn your tears, sweat, saliva, urine, feces, and contact lenses a red-orange color. This effect may be permanent on contact lenses.

This medication may decrease the effectiveness of birth control pills. Talk to your doctor about using another form of birth control during treatment.

Avoid alcohol while taking isoniazid and rifampin. Alcohol will increase the risk of damage to your liver during treatment with this medication.

Use caution with the foods listed below. They can interact with isoniazid and rifampin and cause a reaction that includes a severe headache, large pupils, neck stiffness, nausea, vomiting, diarrhea, flushing, sweating, itching, irregular heartbeats, and chest. A reaction will not necessarily occur, but eat these foods with caution until you know if you will react to them. Call your doctor immediately if you experience any of these symptoms.

Eat the following foods with caution:

  • cheeses, including american, blue, boursault, brick, brie, camembert, cheddar, emmenthaler, gruyere, mozzarella, parmesan, romano, roquefort, stilton, and swiss;
  • sour cream and yogurt;
  • beef or chicken liver, fish, meats prepared with tenderizer, bologna, pepperoni, salami, summer sausage, game meat, meat extracts, caviar, dried fish, herring, shrimp paste, and tuna;
  • avocados, bananas, figs, raisins, and sauerkraut;
  • soy sauce, miso soup, bean curd, and fava beans;
  • yeast extracts;
  • ginseng;
  • chocolate;
  • caffeine (coffee, tea, cola, etc.); and
  • beer (alcoholic and nonalcoholic), red wine (especially Chianti), sherry, vermouth, and other distilled spirits.

What other drugs will affect isoniazid and rifampin (Rifamate)?

Before taking isoniazid and rifampin, tell your doctor if you are taking any of the following drugs:

  • antacids;
  • ketoconazole (Nizoral), fluconazole (Diflucan), or itraconazole (Sporanox);
  • disulfiram (Antabuse);
  • warfarin (Coumadin);
  • carbamazepine (Tegretol);
  • cycloserine (Seromycin);
  • phenytoin (Dilantin), ethotoin (Peganone), and mephenytoin (Mesantoin);
  • meperidine (Demerol);
  • benzodiazepines such as alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril).
  • acetaminophen (Tylenol, others);
  • blood thinners such as warfarin (Coumadin);
  • barbiturates such as phenobarbital (Luminal, Solfoton), amobarbital (Amytal), secobarbital (Seconal), and butabarbital (Butisol);
  • beta-blockers such as atenolol (Tenormin), propranolol (Inderal), and metoprolol (Lopressor);
  • heart medicines such as digoxin (Lanoxin), disopyramide (Norpace), quinidine (Quinora, Quinidex, Cardioquin, others), mexiletine (Mexitil), tocainide (Tonocard), verapamil (Calan, Verelan, Isoptin), and enalapril (Vasotec);
  • corticosteroids such as prednisone (Deltasone, Orasone, Meticorten), prednisolone (Delta Cortef, Prelone, others), methylprednisolone (Medrol), and betamethasone (Celestone);
  • sulfonylureas such as glipizide (Glucotrol), glyburide (Micronase, Diabeta, Glynase), chlorpropamide (Diabinese), tolbutamide (Orinase), and tolazamide (Tolinase);
  • sulfa medicines such as sulfamethoxazole (Bactrim, Septra, Gantanol, Azo-Gantanol), and sulfisoxazole (Gantrisin, Azo-Gantrisin);
  • the HIV and AIDS medicines delavirdine (Rescriptor), saquinavir (Invirase), ritonavir (Norvir), indinavir (Crixivan), nelfinavir (Viracept), and zidovudine (Retrovir);
  • estrogens such as Premarin, Ogen, Estrace, Menest, Estratab, Ortho-Est, and others;
  • oral birth control pills such as Triphasil, Ortho-Novum, Ortho-Cyclen, Ortho-Tri-Cyclen, Ovral, Lo/Ovral, Desogen, Nordette, Levora, Levlen, Tri-Levlen, Nelova, Norinyl, Brevicon, Ovcon, Loestrin, Demulen, and others;
  • phenytoin (Dilantin), ethotoin (Peganone), and mephenytoin (Mesantoin);
  • theophylline (Theolair, Theo-Dur, Theochron, Theo-Bid, others);
  • methadone (Dolophine);
  • clofibrate (Atromid-S); or
  • cyclosporine (Sandimmune, Neoral).

You may not be able to take isoniazid and rifampin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with isoniazid and rifampin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about isoniazid and rifampin written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 2.05. Revision date: 12/15/2010.

Your use of the content provided in this service indicates that you have read,understood and agree to the End-User License Agreement,which can be accessed by clicking on this link.


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