"The cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) has received a green light from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP).
Orkambi is a fixed-dose oral combination "...
Rifater Patient Information including If I Miss a Dose
In this Article
- What is isoniazid, pyrazinamide, and rifampin (Rifater)?
- What are the possible side effects of isoniazid, pyrazinamide, and rifampin (Rifater)?
- What is the most important information I should know about isoniazid, pyrazinamide, and rifampin (Rifater)?
- What should I discuss with my healthcare provider before taking isoniazid, pyrazinamide, and rifampin (Rifater)?
- How should I take isoniazid, pyrazinamide, and rifampin (Rifater)?
- What happens if I miss a dose (Rifater)?
- What happens if I overdose (Rifater)?
- What should I avoid while taking isoniazid, pyrazinamide, and rifampin (Rifater)?
- What other drugs will affect isoniazid, pyrazinamide, and rifampin (Rifater)?
- Where can I get more information?
What happens if I miss a dose (Rifater)?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Rifater)?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include nausea, vomiting, slurred speech, hallucinations, and seizure.
What should I avoid while taking isoniazid, pyrazinamide, and rifampin (Rifater)?
Avoid drinking alcohol while taking isoniazid, pyrazinamide, and rifampin. Alcohol may increase your risk of liver damage.
If you take an antacid, avoid taking it within 1 hour after you have taken isoniazid, pyrazinamide, and rifampin. Antacids can make it harder for your body to absorb rifampin.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, stop taking this medication and call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Certain foods can interact with isoniazid, pyrazinamide, and rifampin, causing unpleasant side effects. Avoid foods that are high in tyramine, including:
- avocados, bananas, figs, raisins, and sauerkraut;
- beef or chicken liver, fish, meats prepared with tenderizer, bologna, pepperoni, salami, summer sausage, game meat, meat extracts, caviar, dried fish, herring, and shrimp paste;
- beer (alcoholic and nonalcoholic), red wine (especially Chianti), sherry, vermouth, and other distilled spirits;
- caffeine (including coffee, tea, cola); and
- cheeses, including American, blue, boursault, brick, brie, camembert, cheddar, emmenthaler, gruyere, mozzarella, parmesan, romano, roquefort, stilton, and Swiss;
- sour cream and yogurt;
- soy sauce, miso soup, bean curd, fava beans; or
- yeast extracts.
Do not wear soft contact lenses while taking isoniazid, pyrazinamide, and rifampin. This medicine may turn certain body fluids a red color (including tears, saliva, urine, and sweat). While this is a harmless side effect, it may permanently stain contact lenses.
What other drugs will affect isoniazid, pyrazinamide, and rifampin (Rifater)?
Many drugs can interact with isoniazid, pyrazinamide, and rifampin. Below is just a partial list. Tell your doctor if you are using:
- cyclosporine (Gengraf, Neoral, Sandimmune);
- haloperidol (Haldol);
- nortriptyline (Pamelor),
- probenecid (Benemid);
- theophylline (Elixophyllin, Theo-24, Uniphyl);
- an antibiotic such as ciprofloxacin (Cipro), clarithromycin (Biaxin), dapsone, erythromycin (E.E.S., Erythrocin, Ery-Tab), and others;
- antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral);
- a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
- birth control pills or hormone replacement therapy;
- a blood thinner such as warfarin (Coumadin);
- diabetes medications you take by mouth;
- heart or blood pressure medication such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), digoxin (Lanoxin), diltiazem (Cartia, Cardizem), metoprolol (Toprol), propranolol (Inderal), nifedipine (Procardia), verapamil (Covera, Isoptin, Verelan), and others;
- heart rhythm medication such as disopyramide (Norpace), mexiletine (Mexitil), quinidine (Quinaglute, Quinidex, Quin-Release);
- narcotic medications such as buprenorphine (Buprenex, Subutex), fentanyl (Actiq, Duragesic, Fentora), methadone (Dolophine, Methadose);
- a sedative such as diazepam (Valium);
- seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), primidone (Mysoline), valproic acid (Depakene);
- a steroid such as prednisolone; or
- a sulfa drug (Cotrim, Bactrim, Septra, SMX-TMP, and others).
There are many other medicines that can interact with isoniazid, pyrazinamide, and rifampin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
Where can I get more information?
Your pharmacist can provide more information about isoniazid, pyrazinamide, and rifampin.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Additional Rifater Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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