"It only takes one bad apple to spoil the bunch, and the same may be true of certain proteins in the brain. Studies have suggested that just one rogue protein (in this case, a protein that is misfolded or shaped the wrong way) can act as a seed"...
No specific antidote or information on treatment of overdosage with RILUTEK (riluzole) is available. In the event of overdose, RILUTEK (riluzole) therapy should be discontinued immediately. Experience with riluzole overdose in humans is limited. Neurological and psychiatric symptoms, acute toxic encephalopathy with stupor, coma, and methemoglobinemia have been observed in isolated cases. Treatment should be supportive and directed toward alleviating symptoms.
Severe methemoglobinemia may be rapidly reversible after treatment with methylene blue. The estimated oral median lethal dose is 94 mg/kg and 39 mg/kg for male mice and rats, respectively.
RILUTEK (riluzole) is contraindicated in patients who have a history of severe hypersensitivity reactions to riluzole or any of the tablet components.
Last reviewed on RxList: 8/4/2009
This monograph has been modified to include the generic and brand name in many instances.
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