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No specific antidote or information on treatment of overdosage with RILUTEK is available. In the event of overdose, RILUTEK therapy should be discontinued immediately. Experience with riluzole overdose in humans is limited. Neurological and psychiatric symptoms, acute toxic encephalopathy with stupor, coma, and methemoglobinemia have been observed in isolated cases. Treatment should be supportive and directed toward alleviating symptoms.
Severe methemoglobinemia may be rapidly reversible after treatment with methylene blue. The estimated oral median lethal dose is 94 mg/kg and 39 mg/kg for male mice and rats, respectively.
RILUTEK is contraindicated in patients who have a history of severe hypersensitivity reactions to riluzole or any of the tablet components.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 3/17/2016
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