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RIMSO-50® brand of dimethyl sulfoxide is indicated for the symptomatic relief of patients with interstitial cystitis. RIMSO-50® (dmso) solution has not been approved as being safe and effective for any other indication. There is no clinical evidence of effectiveness of dimethyl sulfoxide in the treatment of bacterial infections of the urinary tract.
DOSAGE AND ADMINISTRATION
Instillation of 50 mL of RIMSO-50® brand of dimethyl sulfoxide directly into the bladder may be accomplished by catheter or syringe and allow to remain for 15 minutes. Application of an analgesic lubricant gel such as lidocaine jelly to the urethra is suggested prior to insertion of the catheter to avoid spasm. The medication is expelled by spontaneous voiding.
It is recommended that the treatment be repeated every two weeks until maximum symptomatic relief is obtained. Thereafter, time intervals between therapy may be increased appropriately.
Administration of oral analgesic medication suppositories containing belladonna and opium prior to the instillation of RIMSO-50® (dmso) solution can reduce bladder spasm.
In patients with severe interstitial cystitis with very sensitive bladders, the initial treatment, and possibly the second and third (depending on patient response) should be done under anesthesia. (Saddle block has been suggested.)
Bottles contain 50 mL of sterile and non-pyrogenic RIMSO-50® (dmso) (50% w/w dimethyl sulfoxide aqueous solution).
Dimethyl sulfoxide is clear and colorless.
Protect from strong light. Store at room temperatures 59° to 86° F (15° to 30°C).
1. Photographs courtesy of Interstitial Cystitis Association and C. Lowell Parsons, M.D.
2. Erickson DR. Interstitial Cystitis: Update on Etiologies and Therapeutic Options. J Women's Health & Gender-Based Med 1999; 6:745.
3. Parkin J, et al. Intravesical Dimethyl Sulfoxide (DMSO) for Interstitial Cystitis -A Practical Approach. Urology, 1997; 49(5A, Suppl):106.
4. Sant GR, et al. Intravesical 50% Dimethyl Sulfoxide (RIMSO-50® (dmso) solution) in Treatment of Interstitial Cystitis. Urology 1987; 29(4, Suppl):19.
Manufactured for: Bioniche Pharma USA LLC, Lake Forest, IL 60045. Manufactured by: Bioniche Teo., Inverin, Co. Galway, Ireland.
Last reviewed on RxList: 4/9/2009
This monograph has been modified to include the generic and brand name in many instances.
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