Robaxisal (Methocarbamol and Aspirin) Drug Information: Warnings and Precautions

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May 27, 2012

Robaxisal

Muscle Pain (Myofascial Pain Syndrome) »

Introduction

Myofascial pain syndrome (MPS) is a fancy way to describe muscle pain. It refers to pain and inflammation in the body's soft tissues.

Myofascial pain is a chronic condition that affects the fascia (connective tissue that covers the muscles). Myofascial pain syndrome may involve either a single muscle or a muscle group. In some cases, the area where a person experiences the pain may not be where the myofascial pain generator is located. Experts believe that the actual site of the injury or the strain prompts the development of a trigger point that, in turn, causes pain in other areas. This situation is known as referred pain.

What causes myofascial pain?

Myofascial pain may develop from a muscle injury or from excessive strain on a particular muscle or muscle group, ligament or tendon. Other causes include:

Injury to intervertebral disc
General fatigue

Read the Muscle Pain (Myofascial Pain Syndrome) article »

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

WARNINGS

Since methocarbamol may possess a general central nervous system depressant effect, patients receiving Robaxisal (methocarbamol and aspirin) should be cautioned about combined effects with alcohol and other CNS depressants.

PRECAUTIONS

Products containing aspirin should be administered with caution to patients with gastritis or peptic ulceration, or those receiving hypoprothrombinemic anticoagulants.

Methocarbamol may cause a color interference in certain screening tests for 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA).

PREGNANCY

Safe use of Robaxisal (methocarbamol and aspirin) has not been established with regard to possible adverse effects upon fetal development. Therefore, Robaxisal (methocarbamol and aspirin) should not be used in women who are or may become pregnant and particularly during early pregnancy unless in the judgment of the physician the potential benefits outweigh the possible hazards.

NURSING MOTHERS

It is not known whether methocarbamol is secreted in human milk; however, aspirin does appear in human milk in moderate amounts. It can produce a bleeding tendency either by interfering with the function of the infant's platelets or by decreasing the amount of prothrombin in the blood. The risk is minimal if the mother takes the aspirin just after nursing and if the infant has an adequate store of vitamin K. As a general rule, nursing should not be undertaken while a patient is on a drug.

PEDIATRIC USE

Safety and effectiveness in children 12 years of age and below have not been established.

USE IN ACTIVITIES REQUIRING MENTAL ALERTNESS

Robaxisal (methocarbamol and aspirin) may rarely cause drowsiness. Until the patient's response has been determined, he should be cautioned against the operation of motor vehicles or dangerous machinery.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.