Robinul (Glycopyrrolate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Robinul

Peptic Ulcer »

Peptic ulcer facts

Peptic ulcers are sores in the lining of the stomach or duodenum.
Peptic ulcer formation is related to H. pylori bacteria in the stomach and nonsteroidal anti-inflammatory medications (NSAIDs) in 50% of patients. For the remaining 50% there are miscellaneous or unknown causes.
Ulcer pain may not correlate with the presence or severity of ulceration.
The main symptom of peptic ulcer is upper abdominal pain which can be dull, sharp, or burning. (Bloating and burping are not symptoms of peptic ulcer, and vomiting, poor appetite, and nausea are uncommon symptoms of peptic ulcer.)
Diagnosis of ulcer is made with upper GI series or endoscopy.
Treatment of ulcers involves antibiotic combinations along with stomach acid suppression to eradicate H. pylori, eliminating precipitating factors such as NSAIDs and stomach acid suppression...

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Robinul Injection
(Glycopyrrolate) Injection, USP

NOT FOR USE IN NEONATES

CONTAINS BENZYL ALCOHOL

DRUG DESCRIPTION

Robinul (glycopyrrolate) Injection is a synthetic anticholinergic agent. Each 1 mL contains:

Glycopyrrolate, USP 0.2 mg
Water for Injection, USP q.s.
Benzyl Alcohol, NF 0.9% (preservative)
pH adjusted, when necessary, with hydrochloric acid and/or sodium hydroxide.

For Intramuscular (IM) or Intravenous (IV) administration.

Glycopyrrolate is a quaternary ammonium salt with the following chemical name: 3[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl pyrrolidinium bromide. The molecular formulas is C₁₉H₂₈BrNO₃ and the molecular weight is 398.33.

Its structural formula is as follows:

Robinul (glycopyrrolate) structural formula illustration

Glycopyrrolate occurs as a white, odorless crystalline powder. It is soluble in water and alcohol, and practically insoluble in chloroform and ether.

Unlike atropine, glycopyrrolate is completely ionized at physiological pH values. Robinul (glycopyrrolate) Injection is a clear, colorless, sterile liquid; pH 2.0 - 3.0. The partition coefficient of glycopyrrolate in a n-octanol /water system is 0.304 (log₁₀ P= -1.52) at ambient room temperature (24°C).

What are the possible side effects of glycopyrrolate (Robinul, Robinul Forte)?

If you experience any of the following serious side effects, stop taking glycopyrrolate and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
an irregular or fast heart rate;
rash or flushing; or
eye pain.

Other, less serious side effects may be more likely to occur. Continue to take glycopyrrolate and talk to your doctor if you experience

...

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What are the precautions when taking glycopyrrolate (Robinul)?

Before taking glycopyrrolate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, enlarged prostate, problems with urination due to a blocked urinary tract, other stomach/intestinal problems (such as slow gut, blockage, ulcerative colitis, infection, ileostomy/colostomy patients with diarrhea), overactive thyroid, heart problems (such as coronary artery disease, angina, congestive heart failure, fast/irregular heartbeat, heart problems due to severe bleeding), high blood pressure, heartburn...

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Last reviewed on RxList: 12/12/2007
This monograph has been modified to include the generic and brand name in many instances.