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Robinul

Last reviewed on RxList: 9/22/2016
Robinul Side Effects Center

Last reviewed on RxList 9/21/2016

Robinul Injection (glycopyrrolate) is an anticholinergic that helps to control conditions such as peptic ulcers that involve excessive stomach acid production. The injectable form of Robinul is also used to reduce saliva, nasal, lung, and stomach secretions and to help control heart rate during surgery. Robinul Injection is available in generic form. Common side effects of Robinul Injection include:

  • drowsiness,
  • dizziness,
  • weakness,
  • blurred vision,
  • dry eyes,
  • dry mouth,
  • vomiting,
  • constipation,
  • abdominal bloating,
  • stuffy nose,
  • sinus pain, or
  • flushing (warmth, redness, or tingly feeling).

Tell your doctor if you experience unlikely but serious side effects of Robinul Injection including:

  • decreased sweating,
  • fast/irregular heartbeat,
  • mental/mood changes (such as confusion, hallucinations, agitation, nervousness, unusual excitement),
  • difficulty urinating, or
  • decreased sexual ability.

Robinul injection is administered intramuscularly (IM) or intravenously (IV), under a physician's supervision. Dose depends on the condition being treated. Robinul may interact with amantadine, quinidine, antihistamines, decongestants, appetite suppressants, phenothiazines, or antidepressants. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy, Robinul should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Robinul Injection (glycopyrrolate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Robinul Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using glycopyrrolate and call your doctor at once if you have a serious side effect such as:

  • severe constipation, severe stomach pain and bloating;
  • diarrhea (especially if you have a colostomy or ileostomy);
  • feeling like you might pass out;
  • feeling very thirsty or hot, being unable to urinate, heavy sweating, weak pulse, or hot and dry skin; or
  • dry diapers, fussiness, or excessive crying in a child taking glycopyrrolate.

Less serious side effects may include:

  • dry mouth;
  • vomiting;
  • mild constipation;
  • stuffy nose, sinus pain; or
  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Robinul (Glycopyrrolate)

Robinul Professional Information

SIDE EFFECTS

Anticholinergics, including ROBINUL Injection, can produce certain effects, most of which are extensions of their pharmacologic actions. Adverse reactions may include xerostomia (dry mouth); urinary hesitancy and retention; blurred vision and photophobia due to mydriasis (dilation of the pupil); cycloplegia; increased ocular tension; tachycardia; palpitation; decreased sweating; loss of taste; headache; nervousness; drowsiness; weakness; dizziness; insomnia; nausea; vomiting; impotence; suppression of lactation; constipation; bloated feeling; severe allergic reactions including anaphylactic/anaphylactoid reactions; hypersensitivity; urticaria, pruritus, dry skin, and other dermal manifestations; some degree of mental confusion and/or excitement, especially in elderly persons.

In addition, the following adverse events have been reported from post-marketing experience with ROBINUL: malignant hyperthermia; cardiac arrhythmias (including bradycardia, ventricular tachycardia, ventricular fibrillation); cardiac arrest; hypertension; hypotension; seizures; and respiratory arrest. Postmarketing reports have included cases of heart block and QTc interval prolongation associated with the combined use of glycopyrrolate and an anticholinesterase. Injection site reactions including pruritus, edema, erythema, and pain have also been reported.

ROBINUL is chemically a quaternary ammonium compound; hence, its passage across lipid membranes, such as the blood-brain barrier is limited in contrast to atropine sulfate and scopolamine hydrobromide. For this reason the occurrence of CNS-related side effects is lower, in comparison to their incidence following administration of anticholinergics which are chemically tertiary amines that can cross this barrier readily.

Read the entire FDA prescribing information for Robinul (Glycopyrrolate)

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© Robinul Patient Information is supplied by Cerner Multum, Inc. and Robinul Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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