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There are no reports of overdosage, but repeated large doses of interferon can be associated with profound lethargy, fatigue, prostration, and coma. Such patients should be hospitalized for observation and appropriate supportive treatment given.


Roferon-A (interferon alfa-2a, recombinant) is contraindicated in patients with:

  • Hypersensitivity to Roferon-A (interferon alfa-2a, recombinant) or any of its components
  • Autoimmune hepatitis
  • Hepatic decompensation (Child-Pugh class B and C) before or during treatment

Roferon-A (interferon alfa-2a, recombinant) is contraindicated in neonates and infants because it contains benzyl alcohol. Benzyl alcohol is associated with an increased incidence of neurologic and other complications in neonates and infants, which are sometimes fatal.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 11/11/2008


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