"NEW YORK (Reuters Health) - Treatment with masitinib can be helpful when severely symptomatic indolent systemic mastocytosis is unresponsive to optimal treatments, according to a multinational trial.
In a paper online January 6 in The"...
Antihistaminic and decongestant actions
Chlorpheniramine maleate possesses H1 antihistaminic activity and mild anticholinergic and sedative effects. Peak plasma concentration is reached in 5 hours. Urinary excretion is the major route of elimination. The liver is assumed to be the major site of metabolic transformation.
Phenylephrine hydrochloride is an oral sympathomimetic amine that acts as a decongestant to respiratory tract mucous membranes. While its vasoconstrictor action is similar to that of ephedrine, phenylephrine has less pressor effect in normotensive adults. Serum half-life for phenylephrine is 6 to 8 hours. Acidic urine is associated with faster elimination of the drug. About one-half of the administered dose is excreted in the urine.
Last reviewed on RxList: 4/9/2009
This monograph has been modified to include the generic and brand name in many instances.
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