ROTARIX®
(rotavirus) Vaccine, Live Oral Suspension
ROTARIX (Rotavirus Vaccine, Live, Oral), for oral administration, is a live, attenuated rotavirus vaccine derived from the human 89-12 strain which belongs to G1P[8] type. The rotavirus strain is propagated on Vero cells. After reconstitution, the final formulation (1 mL) contains at least 106.0 median Cell Culture Infective Dose (CCID50) of live, attenuated rotavirus.
The lyophilized vaccine contains amino acids, dextran, Dulbecco's Modified Eagle Medium (DMEM), sorbitol, and sucrose. DMEM contains the following ingredients: sodium chloride, potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, and phenol red. The liquid diluent contains calcium carbonate, sterile water, and xanthan. The diluent includes an antacid component (calcium carbonate) to protect the vaccine during passage through the stomach and prevent its inactivation due to the acidic environment of the stomach.
ROTARIX (rotavirus vaccine, live, oral suspension) contains no preservatives.
The tip cap and the rubber plunger of the oral applicator contain dry natural latex rubber. The vial stopper and transfer adapter are latex-free.
Keep track of any and all side effects your child has after receiving this vaccine. When your child receives another vaccine in the future, you will need to tell the doctor if the first dose caused any side effects. Getting rotavirus disease is much more dangerous to your child's health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects. The risk of serious side effects is extremely low.
Get emergency medical help if your child has any of these signs of an allergic reaction: hives;...
Read All Potential Side Effects and See Pictures of Rotarix »
Before your child takes this vaccine, tell the doctor or pharmacist if your child is allergic to it; or to latex (which may be found in the packaging of some brands); or if he/she has any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this vaccine, tell your doctor or pharmacist your child's medical history, especially of: current fever/illness, current vomiting/diarrhea, stomach/abdominal problems, not gaining weight/growing as expected, blood cancer (such as leukemia, lymphoma), blood disorders (such as hemophilia), immune system problems (such as HIV/AIDS, SCID).
Family or household members with cancer or weakened immune systems may rarely become...
Last reviewed on RxList: 10/30/2009
This monograph has been modified to include the generic and brand name in many instances.
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