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RotaTeq

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RotaTeq

RotaTeq
(rotavirus vaccine, live, oral, pentavalent) Oral Solution

RotaTeq

DRUG DESCRIPTION

RotaTeq (rotavirus vaccine, live, oral, pentavalent) is a live, oral pentavalent vaccine that contains 5 live reassortant rotaviruses. The rotavirus parent strains of the reassortants were isolated from human and bovine hosts. Four reassortant rotaviruses express one of the outer capsid proteins (G1, G2, G3, or G4) from the human rotavirus parent strain and the attachment protein (serotype P7) from the bovine rotavirus parent strain. The fifth reassortant virus expresses the attachment protein, P1A (genotype P[8]), herein referred to as serotype P1A[8], from the human rotavirus parent strain and the outer capsid protein of serotype G6 from the bovine rotavirus parent strain (see Table 7).

Table 7

Name of
Reassortant
Human Rotavirus
Parent Strains and Outer Surface Protein Compositions
Bovine Rotavirus
Parent Strain and Outer Surface Protein Composition
Reassortant
Outer Surface Protein Composition (Human Rotavirus Componentin Bold)
Minimum Dose Levels
(106 infectious units)
G1 WI79 - G1P1A[8] WC3 - G6, P7[5] G1P7[5] 2.2
G2 SC2 - G2P2[6] G2P7[5] 2.8
G3 WI78 - G3P1A[8] G3P7[5] 2.2
G4 BrB - G4P2[6] G4P7[5] 2.0
P1A[8] WI79 - G1P1A[8] G6P1A[8] 2.3

The reassortants are propagated in Vero cells using standard cell culture techniques in the absence of antifungal agents.

The reassortants are suspended in a buffered stabilizer solution. Each vaccine dose contains sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, and trace amounts of fetal bovine serum.

RotaTeq (rotavirus vaccine, live, oral, pentavalent) contains no preservatives. RotaTeq (rotavirus vaccine, live, oral, pentavalent) is a pale yellow clear liquid that may have a pink tint.

What are the possible side effects of rotavirus oral vaccine (Rotarix, RotaTeq)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous dose caused any side effects. Becoming infected with rotavirus is much more dangerous to your child's health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of the...

Read All Potential Side Effects and See Pictures of RotaTeq »

What are the precautions when taking rotavirus vaccine, live, oral, pentavalent (RotaTeq)?

Before your child takes this vaccine, tell the doctor or pharmacist if your child is allergic to it; or if he/she has any other allergies. This product may contain inactive ingredients (such as latex found in the packaging of some products), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this vaccine, tell your doctor or pharmacist your child's medical history, especially of: current fever/illness, current vomiting/diarrhea, stomach/intestinal problems (such as blockage, intussusception), not gaining weight/growing as expected, blood cancer (such as leukemia, lymphoma), blood disorders (such as hemophilia), immune system problems (such as HIV/AIDS, SCID).

Family or household members with cancer or weakened...

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Last reviewed on RxList: 8/28/2008
This monograph has been modified to include the generic and brand name in many instances.

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RotaTeq - User Reviews

RotaTeq User Reviews

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