Brand Names: Canasa, Canasa Pac, Rowasa

Generic Name: mesalamine (rectal) (Pronunciation: me SAL a meen)

• What is mesalamine rectal (Rowasa)?
• What are the possible side effects of mesalamine rectal (Rowasa)?
• What is the most important information I should know about mesalamine rectal (Rowasa)?
• What should I discuss with my health care provider before taking mesalamine rectal (Rowasa)?
• How should I use mesalamine rectal (Rowasa)?
• What happens if I miss a dose (Rowasa)?
• What happens if I overdose (Rowasa)?
• What should I avoid while taking mesalamine rectal (Rowasa)?
• What other drugs will affect mesalamine rectal (Rowasa)?
• Where can I get more information?

What is mesalamine rectal (Rowasa)?

Mesalamine affects a substance in the body that causes inflammation, tissue damage, and diarrhea.

Mesalamine rectal is used to treat ulcerative colitis, proctitis, and proctosigmoiditis. Mesalamine is also used to prevent the symptoms of ulcerative colitis from recurring.

Mesalamine rectal may also be used for other purposes not listed in this medication guide.

What are the possible side effects of mesalamine rectal (Rowasa)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using mesalamine rectal and call your doctor at once if you have severe stomach pain, cramping, fever, headache, and bloody diarrhea.

Less serious side effects may include:

• mild nausea, vomiting, stomach cramps, diarrhea, gas;
• fever, sore throat, or other flu symptoms;
• rectal pain, constipation;
• headache or dizziness;
• tired feeling; or
• skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the Rowasa (mesalamine rectal suspension enema) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about mesalamine rectal (Rowasa)?

Do not take mesalamine rectal by mouth. It is for use only in your rectum.

Tell your doctor if you have any type of kidney or liver disease, or if you are allergic to aspirin. You may not be able to use mesalamine, or you may need a dosage adjustment or special tests during treatment.

This medication comes with patient instructions for using either the rectal suppository or the rectal enema. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Try to empty your bowel and bladder just before using the mesalamine suppository or enema. Try to use the medicine at a time when you can lie down afterward and hold the medicine in. Avoid using the bathroom during this time. It may be best to use this medicine at bedtime.

Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.

Shake the rectal enema liquid well just before each use.

The rectal enema liquid may darken in color after it has been removed from the foil pouch. This should not affect the medicine. However, throw away any enema liquid that has turned dark brown.

Stop using mesalamine and call your doctor at once if you have severe stomach pain, cramping, fever, headache, and bloody diarrhea.

Avoid getting the rectal suppositories or enema liquid on clothing, flooring, painted surfaces, vinyl, marble, granite, and other surfaces. Mesalamine rectal products may stain surfaces.