Salagen (Pilocarpine Hydrochloride) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Salagen

Sjogren's Syndrome »

Sjögren's syndrome facts

Sjögren's syndrome is an autoimmune disease.
Sjögren's syndrome involves inflammation of glands and other tissues of the body.
About 90% of Sjögren's syndrome patients are female.
Sjögren's syndrome can be complicated by infections of the eyes, breathing passages, and mouth.
Sjögren's syndrome is typically associated with antibodies against a variety of body tissues (autoantibodies).
Diagnosis of Sjögren's syndrome can be aided by a saliva-gland biopsy.
Treatment of patients with Sjögren's syndrome is directed toward the particular areas of the body that are involved and complications, such as infection.

What is Sjögren's syndrome?

SjÃ¶gren's syndrome is an autoimmune disease characterized by dryness of the mouth and eyes. Autoimmune diseases feature the abnormal pr...

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SALAGEN®
(pilocarpine hydrochloride) Tablets

DRUG DESCRIPTION

SALAGEN® Tablets contain pilocarpine hydrochloride, a cholinergic agonist for oral use. Pilocarpine hydrochloride is a hygroscopic, odorless, bitter tasting white crystal or powder which is soluble in water and alcohol and virtually insoluble in most nonpolar solvents. Pilocarpine hydrochloride, with a chemical name of (3S-cis)-2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl) methyl] monohydrochloride, has a molecular weight of 244. 72.

SALAGEN® (pilocarpine hydrochloride) Structural Formula Illustration

Each 5 mg SALAGEN® (pilocarpine hydrochloride) Tablet for oral administration contains 5 mg of pilocarpine hydrochloride. Inactive ingredients in the tablet, the tablet's film coating, and polishing are: carnauba wax, hydroxypropyl methylcellulose, microcrystalline cellulose, stearic acid, titanium dioxide and other ingredients.

Each 7. 5 mg SALAGEN® (pilocarpine hydrochloride) Tablet for oral administration contains 7. 5 mg of pilocarpine hydrochloride. Inactive ingredients in the tablet, the tablet's film coating, and polishing are: carnauba wax, hydroxypropyl methylcellulose, microcrystalline cellulose, stearic acid, titanium dioxide, FD&C blue#2 aluminum lake, and other ingredients.

What are the possible side effects of pilocarpine (Salagen)?

Stop taking pilocarpine and seek emergency medical attention if you experience any of the following uncommon but serious side effects:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
difficulty breathing;
irregular heartbeats;
eye pain; or
confusion or changes in mental status or behavior.

Other, less serious side effects may also occur. Continue to take pilocarpine and talk to your doctor if you...

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What are the precautions when taking pilocarpine hydrochloride (Salagen)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic bronchitis, chronic obstructive pulmonary disease-COPD), certain eye conditions (such as night blindness, acute iritis, narrow-angle glaucoma), heart disease (such as chest pain, heart failure, heart attack, slow heartbeat), low or high blood pressure, liver problems, gallbladder disease (such as gallstones), kidney stones, mental/mood disorders (such as depression, psychoses,...

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Last reviewed on RxList: 10/9/2008
This monograph has been modified to include the generic and brand name in many instances.