Salagen (Pilocarpine Hydrochloride) Drug Information: Overdosage and Contraindications

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May 27, 2012

Salagen

Sjogren's Syndrome »

Sjögren's syndrome facts

Sjögren's syndrome is an autoimmune disease.
Sjögren's syndrome involves inflammation of glands and other tissues of the body.
About 90% of Sjögren's syndrome patients are female.
Sjögren's syndrome can be complicated by infections of the eyes, breathing passages, and mouth.
Sjögren's syndrome is typically associated with antibodies against a variety of body tissues (autoantibodies).
Diagnosis of Sjögren's syndrome can be aided by a saliva-gland biopsy.
Treatment of patients with Sjögren's syndrome is directed toward the particular areas of the body that are involved and complications, such as infection.

What is Sjögren's syndrome?

Sjögren's syndrome is an autoimmune disease characterized by dryness of the mouth and eyes. Autoimmune diseases feature the abnormal pr...

Read the Sjogren's Syndrome article »

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OVERDOSE

Management Of Overdose

Fatal overdosage with pilocarpine has been reported in the scientific literature at doses presumed to be greater than 100 mg in two hospitalized patients. 100 mg of pilocarpine is considered potentially fatal. Overdosage should be treated with atropine titration (0.5 mg to 1.0 mg given subcutaneously or intravenously) and supportive measures to maintain respiration and circulation. Epinephrine (0.3 mg to 1.0 mg, subcutaneously or intramuscularly) may also be of value in the presence of severe cardiovascular depression or bronchoconstriction. It is not known if pilocarpine is dialyzable.

CONTRAINDICATIONS

SALAGEN® Tablets are contraindicated in patients with uncontrolled asthma, known hypersensitivity to pilocarpine, and when miosis is undesirable, e.g., in acute iritis and in narrow-angle (angle closure) glaucoma.

Last reviewed on RxList: 4/16/2012
This monograph has been modified to include the generic and brand name in many instances.