Sanctura (Trospium) Drug Information: Medication Guide and Patient Information

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May 27, 2012

Sanctura

Overactive Bladder »

What is an overactive bladder?

An overactive bladder is a condition that results from sudden, involuntary contraction of the muscle in the wall of the urinary bladder. Overactive bladder causes a sudden and unstoppable need to urinate (urinary urgency), even though the bladder may only contain a small amount of urine.

Overactive bladder is also referred to as urge incontinence and is a form of urinary incontinence (unintentional loss of urine). Another common type of urinary incontinence is called stress incontinence, which is caused by anatomic weakness in the structures that prevent the bladder from leaking. In general, urinary incontinence is more common in women compared to men.

Although it can happen at any age, overactive bladder is especially common in older adults. Overactive bladder affects an estimated one in 11 adults in the United States. Overactive bladder, however, should not be considered a normal part of aging.

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PATIENT INFORMATION

Patients should be informed that trospium chloride may produce angioedema which could result in life-threatening airway obstruction. Patients should be advised to promptly discontinue trospium chloride and seek immediate medical attention if they experience edema of the tongue, edema of the laryngopharynx, or difficulty breathing.

Patients should be informed that anticholinergic agents, such as SANCTURA®, may produce clinically significant adverse effects related to anticholinergic pharmacological activity. For example, heat prostration (fever and heat stroke due to decreased sweating) can occur when anticholinergics such as SANCTURA® are used in a hot environment. Because anticholinergics such as SANCTURA® may also produce dizziness or blurred vision, patients should be advised to exercise caution. Patients should be informed that alcohol may enhance the drowsiness caused by anticholinergic agents.

SANCTURA® should be taken 1 hour prior to meals or on an empty stomach. If a dose is skipped, patients are advised to take their next dose 1 hour prior to their next meal.

Last reviewed on RxList: 9/30/2011
This monograph has been modified to include the generic and brand name in many instances.