Recommended Topic Related To:

Sandostatin

"The U.S. Food and Drug Administration today approved Cyramza (ramucirumab) to treat patients with advanced stomach cancer or gastroesophageal junction adenocarcinoma, a form of cancer located in the region where the esophagus joins the stomach./"...

Sandostatin

Sandostatin®
(octreotide acetate) Injection

DRUG DESCRIPTION

Sandostatin® (octreotide acetate) Injection, a cyclic octapeptide prepared as a clear sterile solution of octreotide, acetate salt, in a buffered lactic acid solution for administration by deep subcutaneous (intrafat) or intravenous injection. Octreotide acetate, known chemically as L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-Lthreonyl-N-[2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide; [R-(R*, R*)] acetate salt, is a long-acting octapeptide with pharmacologic actions mimicking those of the natural hormone somatostatin.

Sandostatin (octreotide acetate) Injection is available as: sterile 1-mL ampuls in 3 strengths, containing 50, 100, or 500 mcg octreotide (as acetate), and sterile 5-mL multi-dose vials in 2 strengths, containing 200 and 1000 mcg/mL of octreotide (as acetate).

Each ampul also contains:

lactic acid, USP............................................. 3.4 mg
mannitol, USP................................................ 45 mg
sodium bicarbonate, USP .............................. qs to pH 4.2 ±0.3
water for injection, USP...................................qs to 1 mL

Each mL of the multi-dose vials also contains:

lactic acid, USP ............................................. 3.4 mg
mannitol, USP................................................. 45 mg
phenol, USP....................................................5.0 mg
sodium bicarbonate, USP ............................... qs to pH 4.2 ±0.3
water for injection, USP...................................qs to 1 mL

Lactic acid and sodium bicarbonate are added to provide a buffered solution, pH to 4.2 ±0.3.

The molecular weight of octreotide acetate is 1019.3 (free peptide, C49H66N10O10S2) and its amino acid sequence is:

Sandostatin (octreotide) amino acid sequence - illustration

H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol,
xCH3COOH           where x = 1.4 to 2.5

What are the possible side effects of octreotide (Sandostatin, Sandostatin LAR Depot)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • slow or uneven heartbeats;
  • severe stomach pain or tenderness, severe constipation;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart...

Read All Potential Side Effects and See Pictures of Sandostatin »

What are the precautions when taking octreotide acetate (Sandostatin)?

Before using octreotide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease (e.g., cirrhosis), diabetes, thyroid problems, gallbladder problems (e.g., gallstones), nutrition problems (e.g., decreased fat absorption, vitamin B12 deficiency).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Caution is advised when using...

Read All Potential Precautions of Sandostatin »

Last reviewed on RxList: 2/22/2010
This monograph has been modified to include the generic and brand name in many instances.

A A A

Sandostatin - User Reviews

Sandostatin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Sandostatin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Cancer

Get the latest treatment options.