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Sandostatin

"A set of proteins involved in the body's natural defenses produces a large number of mutations in human DNA, according to a study led by researchers at the National Institutes of Health. The findings suggest that these naturally produced mutat"...

Sandostatin

Sandostatin®
(octreotide acetate) Injection

Sandostatin

DRUG DESCRIPTION

Sandostatin® (octreotide acetate) Injection, a cyclic octapeptide prepared as a clear sterile solution of octreotide, acetate salt, in a buffered lactic acid solution for administration by deep subcutaneous (intrafat) or intravenous injection. Octreotide acetate, known chemically as L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-Lthreonyl-N-[2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide; [R-(R*, R*)] acetate salt, is a long-acting octapeptide with pharmacologic actions mimicking those of the natural hormone somatostatin.

Sandostatin (octreotide acetate) Injection is available as: sterile 1-mL ampuls in 3 strengths, containing 50, 100, or 500 mcg octreotide (as acetate), and sterile 5-mL multi-dose vials in 2 strengths, containing 200 and 1000 mcg/mL of octreotide (as acetate).

Each ampul also contains:

lactic acid, USP............................................. 3.4 mg
mannitol, USP................................................ 45 mg
sodium bicarbonate, USP .............................. qs to pH 4.2 ±0.3
water for injection, USP...................................qs to 1 mL

Each mL of the multi-dose vials also contains:

lactic acid, USP ............................................. 3.4 mg
mannitol, USP................................................. 45 mg
phenol, USP....................................................5.0 mg
sodium bicarbonate, USP ............................... qs to pH 4.2 ±0.3
water for injection, USP...................................qs to 1 mL

Lactic acid and sodium bicarbonate are added to provide a buffered solution, pH to 4.2 ±0.3.

The molecular weight of octreotide acetate is 1019.3 (free peptide, C49H66N10O10S2) and its amino acid sequence is:

Sandostatin (octreotide) amino acid sequence - illustration

H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol,
xCH3COOH           where x = 1.4 to 2.5

What are the possible side effects of octreotide (Sandostatin, Sandostatin LAR Depot)?

Stop using octreotide and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • slow or irregular heartbeats;
  • gallbladder problems (stomach pain);
  • pancreatitis (pain in the upper stomach or back, nausea, vomiting, fever, bloating, yellowing of the skin or eyes);
  • thyroid problems (may be detected by blood tests);
  • low blood sugar...

Read All Potential Side Effects and See Pictures of Sandostatin »

What are the precautions when taking octreotide acetate (Sandostatin)?

Before using octreotide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease (e.g., cirrhosis), diabetes, thyroid problems, gallbladder problems (e.g., gallstones), nutrition problems (e.g., decreased fat absorption, vitamin B12 deficiency).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Caution is advised when using...

Read All Potential Precautions of Sandostatin »

Last reviewed on RxList: 2/22/2010
This monograph has been modified to include the generic and brand name in many instances.

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Sandostatin - User Reviews

Sandostatin User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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