A limited number of accidental overdoses of Sandostatin® (octreotide acetate) in adults have been reported. In adults, the doses ranged from 2,400–6,000 micrograms/day administered by continuous infusion (100-250 micrograms/hour) or subcutaneously (1,500 micrograms t.i.d.). Adverse events in some patients included arrhythmia, hypotension, cardiac arrest, brain hypoxia, pancreatitis, hepatitis steatosis, hepatomegaly, lactic acidosis, flushing, diarrhea, lethargy, weakness, and weight loss.

Sandostatin (octreotide acetate) Injection given in intravenous boluses of 1 mg (1000 mcg) to healthy volunteers did not result in serious ill effects, nor did doses of 30 mg (30,000 mcg) given intravenously over 20 minutes and of 120 mg (120,000 mcg) given intravenously over 8 hours to research patients.

If overdose occurs, symptomatic management is indicated. Up-to-date information about the treatment of overdose can often be obtained from the National Poison Control Center at 1800-222-1222.

Drug Abuse and Dependence

There is no indication that Sandostatin (octreotide acetate) has potential for drug abuse or dependence. Sandostatin (octreotide acetate) levels in the central nervous system are negligible, even after doses up to 30,000 mcg.

Sensitivity to this drug or any of its components.

Last reviewed on RxList: 2/22/2010
This monograph has been modified to include the generic and brand name in many instances.