May 26, 2017
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Sandostatin LAR

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Sandostatin LAR

Sandostatin® LAR Depot
(octreotide acetate) for injectable suspension


Octreotide is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is known chemically as L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1(hydroxy-methyl) propyl]-, cyclic (2→7)-disulfide; [R-(R*,R*)].

The molecular weight of octreotide is 1019.3 (free peptide, C49H66N10O10S2) and its amino acid sequence is:

Sandostatin® LAR Depot (octreotide acetate) Structural Formula Illustration

Sandostatin LAR Depot is available in a vial containing the sterile drug product, which when mixed with diluent, becomes a suspension that is given as a monthly intragluteal injection. The octreotide is uniformly distributed within the microspheres which are made of a biodegradable glucose star polymer, D,L-lactic and glycolic acids copolymer. Sterile mannitol is added to the microspheres to improve suspendability.

Sandostatin LAR Depot is available as: sterile 6-mL vials in 3 strengths delivering 10 mg, 20 mg, or 30 mg octreotide-free peptide. Each vial of Sandostatin LAR Depot delivers:

Name of Ingredient 10 mg 20 mg 30 mg
octreotide acetate 11.2 mg* 22.4 mg* 33.6 mg*
D,L-lactic and glycolic acids copolymer 188.8 mg 377.6 mg 566.4 mg
mannitol 41.0 mg 81.9 mg 122.9 mg
*Equivalent to 10/20/30 mg octreotide base.

Each syringe of diluent contains:

carboxymethylcellulose sodium 14.0 mg
mannitol 12.0 mg
poloxamer 188 4.0 mg
water for injection 2.0 mL

What are the possible side effects of octreotide (Sandostatin, Sandostatin LAR Depot)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • slow or uneven heartbeats;
  • severe stomach pain or tenderness, severe constipation;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart...

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What are the precautions when taking octreotide acetate injection (Sandostatin LAR)?

Before using octreotide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease (e.g., cirrhosis), diabetes, thyroid problems, gallbladder problems (e.g., gallstones), nutrition problems (e.g., decreased fat absorption, vitamin B12 deficiency).

Caution is advised when using this drug in the elderly because they may be more sensitive to its effects.

Caution is advised when using this drug in children. Use of this medication for long periods (e.g., longer than 1...

Read All Potential Precautions of Sandostatin LAR »

Last reviewed on RxList: 8/3/2016
This monograph has been modified to include the generic and brand name in many instances.

Sandostatin LAR - User Reviews

Sandostatin LAR User Reviews

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