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Sandostatin LAR® Depot
(octreotide acetate) for Injectable Suspension
- Patient Information:
Details with Side Effects
Octreotide is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is known chemically as L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1- (hydroxy-methyl) propyl]-, cyclic (2→7)-disulfide; [R-(R*,R*)].
Sandostatin LAR Depot is available in a vial containing the sterile drug product, which when mixed with diluent, becomes a suspension that is given as a monthly intragluteal injection. The octreotide is uniformly distributed within the microspheres which are made of a biodegradable glucose star polymer, D,L-lactic and glycolic acids copolymer. Sterile mannitol is added to the microspheres to improve suspendability.
Sandostatin LAR Depot is available as: sterile 5-mL vials in 3 strengths delivering 10 mg, 20 mg, or 30 mg octreotide-free peptide. Each vial of Sandostatin LAR Depot delivers:
|Name of Ingredient||10 mg||20 mg||30 mg|
|octreotide acetate||11.2 mg*||22.4 mg*||33.6 mg*|
|D, L-lactic and glycolic acids copolymer||188.8 mg||377.6 mg||566.4 mg|
|mannitol||41.0 mg||81.9 mg||122.9 mg|
|*Equivalent to 10/20/30 mg octreotide base.|
Each syringe of diluent contains:
|carboxymethylcellulose sodium||12.5 mg|
|water for injection||2.5 mL|
The molecular weight of octreotide is 1019.3 (free peptide, C49H66N10O10S2) and its amino acid sequence is
What are the possible side effects of octreotide (Sandostatin, Sandostatin LAR Depot)?
Stop using octreotide and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- slow or irregular heartbeats;
- gallbladder problems (stomach pain);
- pancreatitis (pain in the upper stomach or back, nausea, vomiting, fever, bloating, yellowing of the skin or eyes);
- thyroid problems (may be detected by blood tests);
- low blood sugar...
What are the precautions when taking octreotide acetate injection (Sandostatin LAR)?
Before using octreotide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease (e.g., cirrhosis), diabetes, thyroid problems, gallbladder problems (e.g., gallstones), nutrition problems (e.g., decreased fat absorption, vitamin B12 deficiency).
Caution is advised when using this drug in the elderly because they may be more sensitive to its effects.
Caution is advised when using this drug in children. Use of this medication for long periods (e.g., longer than 1...
Last reviewed on RxList: 10/10/2011
This monograph has been modified to include the generic and brand name in many instances.
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