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home > drugs a-z list > sandostatin lar (octreotide acetate injection) drug center > sandostatin lar (octreotide acetate injection) drug - overdosage and contraindications
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Sandostatin LAR
Diarrhea facts
- Diarrhea is an increase in the frequency of bowel movements, an increase in the looseness of stool or both.
- Diarrhea is caused by increased secretion of fluid into the intestine, reduced absorption of fluid from the intestine or rapid passage of stool through the intestine.
- Diarrhea can be defined absolutely or relatively. Absolute diarrhea is defined as more than five bowel movements a day or liquid stools. Relative diarrhea is defined as an increase in the number of bowel movements per day or an increase in the looseness of stools compared with an individual's usual bowel habit.
- Diarrhea may be either acute or chronic, and each has different causes and treatments.
- Complications of diarrhea include dehydration, electrolytes (mineral) abnormalities, and irritation of the anus.
- Dehydration can be treated with oral ...
Sandostatin LAR
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OVERDOSE
No frank overdose has occurred in any patient to date. Sandostatin Injection given in intravenous bolus doses of 1 mg (1000 mcg) to healthy volunteers did not result in serious ill effects, nor did doses of 30 mg (30,000 mcg) given intravenously over 20 minutes and of 120 mg (120,000 mcg) given intravenously over 8 hours to research patients. Doses of 2.5 mg (2500 mcg) of Sandostatin Injection subcutaneously have, however, caused hypoglycemia, flushing, dizziness, and nausea.
Up-to-date information about the treatment of overdose can often be obtained from a certified Regional Poison Control Center. Telephone numbers of certified Regional Poison Control Centers are listed in the Physicians' Desk Reference®.
Mortality occurred in mice and rats given 72 mg/kg and 18 mg/kg intravenously, respectively, of octreotide.
CONTRAINDICATIONS
None
Last reviewed on RxList: 10/10/2011
This monograph has been modified to include the generic and brand name in many instances.
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Sandostatin LAR
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