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Sansert Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Sansert (methysergide maleate) is an anti-migraine medication used to prevent vascular headaches (e.g., migraines) and to reduce their severity. The brand name of this medication is discontinued, but generic versions may be available. Common side effects include nausea, vomiting, heartburn, abdominal pain, diarrhea, constipation, drowsiness, dizziness, lightheadedness, weakness, poor coordination, insomnia, rash or facial flushing, weight gain, or muscle or joint aches or discomfort.
The usual adult dose of Sansert is 4-8 mg daily, given with meals. Sansert may interact with other migraine headache medicines, beta-blockers, and nicotine. Tell your doctor all medications and supplements you use. Sansert is not recommended for use during pregnancy. It causes birth defects and also can induce uterine contractions and harm the baby. This drug passes into breast milk and can cause vomiting and diarrhea in a nursing infant. Do not take Sansert while breastfeeding.
Our Sansert (methysergide maleate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Sansert FDA Prescribing Information: Side Effects
Within the recommended dose levels, the following side effects have been reported:
1) Fibrotic Complications
Fibrotic changes have been observed in the retroperitoneal, pleuropulmonary, cardiac, and other tissues, either singly or, very rarely, in combination.
This nonspecific fibrotic process is usually confined to the retroperitoneal connective tissue above the pelvic brim and may present clinically with one or more symptoms such as general malaise, fatigue, weight loss, backache, low grade fever (elevated sedimentation rate), urinary obstruction (girdle or flank pain, dysuria, polyuria, oliguria, elevated BUN), vascular insufficiency of the lower limbs (leg pain, Leriche syndrome, edema of legs, thrombophlebitis). The single most useful diagnostic procedure in suspected cases of retroperitoneal fibrosis is intravenous pyelography. Typical deviation and obstruction of one or both ureters may be observed.
A similar nonspecific fibrotic process, limited to the pleural and immediately subjacent pulmonary tissues, usually presents clinically with dyspnea, tightness and pain in the chest, pleural friction rubs, and pleural effusion. These findings may be confirmed by chest X-ray.
Nonrheumatic fibrotic thickenings of the aortic root and of the aortic and mitral valves usually present clinically with cardiac murmurs and dyspnea.
Other Fibrotic Complications
Several cases of fibrotic plaques, simulating Peyronies Disease have been described.
2) Cardiovascular Complications
Encroachment of retroperitoneal fibrosis on the aorta, inferior vena cava and their common iliac branches may result in vascular insufficiency of the lower limbs, the presenting features of which are mentioned under Retroperitoneal Fibrosis.
Intrinsic vasoconstriction of large and small arteries, involving one or more vessels or merely a segment of a vessel, may occur at any stage of therapy. Depending on the vessel involved, this complication may present with chest pain, abdominal pain, or cold, numb, painful extremities with or without paresthesias and diminished or absent pulses. Progression to ischemic tissue damage has rarely been reported. Prompt withdrawal of the drug at the first signs of impaired circulation is recommended (see WARNINGS) to obviate such effects.
3) Gastrointestinal Symptoms
Nausea, vomiting, diarrhea, heartburn, abdominal pain. These effects tend to appear early and can frequently be obviated by gradual introduction of the medication and by administration of the drug with meals. Constipation and elevation of gastric HCl have also been reported.
4) CNS Symptoms
Seizure, insomnia, drowsiness, mild euphoria, dizziness, ataxia, lightheadedness, hyperesthesia, unworldly feelings (described variously as "dissociation", "hallucinatory experiences", etc.). Some of these symptoms may be associated with vascular headaches, per se, and may, therefore, be unrelated to the drug.
5) Dermatological Manifestations
Peripheral edema, and, more rarely, localized brawny edema may occur. Dependent edema has responded to lowered doses, salt restriction, or diuretics.
7) Weight Gain
Weight gain may be a reason to caution patients regarding their caloric intake.
8) Hematological Manifestations
Read the entire FDA prescribing information for Sansert (Methysergide maleate) »
Additional Sansert Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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