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Collagenase Santyl® (collagenase) Ointment is a sterile enzymatic debriding ointment which contains 250 collagenase units per gram of white petrolatum USP. The enzyme collagenase is derived from the fermentation by Clostridium histolyticum. It possesses the unique ability to digest collagen in necrotic tissue.
What are the possible side effects of collagenase topical (Santyl)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if your skin condition gets worse, or you have new symptoms of illness or infection.
Less serious side effects may include redness of the skin around the treated area where collagenase topical was applied.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...
What are the precautions when taking collagenase (Santyl)?
Before using collagenase, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history.
Avoid using solutions that contain acid or metal as soaking liquids because these will decrease the effect of collagenase ointment (see also Drug Interactions section).
It is not known whether this medication passes into breast milk. Consult your doctor before...
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
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