SAPHO Syndrome (cont.)
William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Catherine Burt Driver, MD
Catherine Burt Driver, MD, is board certified in internal medicine and rheumatology by the American Board of Internal Medicine. Dr. Driver is a member of the American College of Rheumatology. She currently is in active practice in the field of rheumatology in Mission Viejo, Calif., where she is a partner in Mission Internal Medical Group.
In this Article
- SAPHO syndrome facts
- What is SAPHO syndrome?
- What causes SAPHO syndrome, and what are risk factors for developing it?
- Is SAPHO syndrome related to other joint conditions?
- What are symptoms and signs of SAPHO syndrome?
- How is SAPHO syndrome diagnosed?
- What is the treatment for SAPHO syndrome?
- What is the outlook (prognosis) for patients with SAPHO syndrome?
- Can SAPHO syndrome be prevented?
- Find a local Rheumatologist in your town
What is treatment for SAPHO syndrome?
Treatment of patients with SAPHO syndrome is directed toward the individual symptoms that are present. Generally, treatment involves medications that reduce inflammation in the particular tissues affected. Examples of medications that are used for inflammation include nonsteroidal anti-inflammatory drugs (NSAIDs, such as aspirin, ibuprofen [Advil, Motrin], and naproxen [Aleve]) and cortisone medications (either in the form of topical creams, tablets, or by injection into the involved area). Topical cold applications can also help reduce inflammation in some tissues. For patients with persisting joint symptoms, both sulfasalazine (Azulfidine) and methotrexate (Rheumatrex, Trexall) have been tried with varying degrees of success. Newer biologic medications, including infliximab (Remicade), have also been used successfully.
What is the outlook (prognosis) for patients with SAPHO syndrome?
To some degree, the outlook for patients with SAPHO syndrome is not predictable but depends on response to medications. When sulfasalazine or methotrexate quiet the symptoms and signs of inflammation, the outlook is optimal.
Can SAPHO syndrome be prevented?
Because the tendency toward developing SAPHO syndrome is inherited, it is not possible to prevent the disease at this time.
Klippel, John H., et al., eds. Primer on the Rheumatic Diseases. 13th ed. New York: Springer and Arthritis Foundation, 2008.
Last Editorial Review: 10/21/2011
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