Livalo (pitavastatin) to Lower High Cholesterol
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
- What is Livalo (pitavastatin)?
- How is Livalo (pitavastatin) prescribed?
- With which drugs does Livalo (pitavastatin) interact?
- What about taking Livalo (pitavastatin) during pregnancy?
- What are the side effects of Livalo (pitavastatin)?
What is Livalo (pitavastatin)?
Livalo (pitavastatin) is a cholesterol-lowering drug approved by the Food and Drug Administration in August 2009. Livalo is an HMG-CoA reductase inhibitor or "statin."
Other statins include:
- Zocor (simvastatin),
- Pravachol (pravastatin),
- Mevacor (lovastatin),
- Lipitor (atorvastatin), and
- Crestor (rosuvastatin).
Statins reduce cholesterol by reducing the activity of HMG-CoA reductase, an enzyme in the liver that is necessary for the production of cholesterol.
In one study Livalo (pitavastatin), 4 mg daily:
- reduced total cholesterol by 32%
- reduced LDL ("bad") cholesterol by 45%,
- reduced triglycerides by 19%,
- reduced apolipoprotein B by 35%, and
- raised HDL ("good") cholesterol by 5%.
The 4 mg dose of Livalo (pitavastatin) is comparable to 20 mg of atorvastatin in reducing cholesterol. However, Livalo increases HDL more than Lipitor (atorvastatin). The 2 mg and 4 mg doses of Livalo are comparable to 20 mg and 40 mg doses of Zocor (simvastatin), respectively.
REFERENCE: FDA.gov. Livalo (pitavastatin) Prescribing Information.
Tips to keep it under control.