Livalo (pitavastatin) to Lower Cholesterol (cont.)
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
In this Article
- What is Livalo (pitavastatin)?
- How is Livalo (pitavastatin) prescribed?
- With which drugs does Livalo (pitavastatin) interact?
- What about taking Livalo (pitavastatin) during pregnancy?
- What are the side effects of Livalo (pitavastatin)?
How is Livalo (pitavastatin) prescribed?
- The usual dose range of Livalo is 1 to 4 mg daily administered at any time of the day without regard to meals.
- Therapy is usually initiated at 2 mg daily and increased after 4 weeks up to a maximum dose of 4 mg daily.
- Doses greater than 4 mg daily are associated with severe muscle toxicity.
- The recommended dose for individuals with moderate renal dysfunction or on dialysis is 1 to 2 mg daily.
With which drugs does Livalo (pitavastatin) interact?
- Sandimmune, Neoral, Restasis, Gengraf Capsules, Gengraf Oral Solution (cyclosporine), erythromycin, Reyataz (atazanavir), Rifadin, Rifamate, Rifater, Priftin (rifampin), and Lopid (gemfibrozil) significantly increase blood levels of Livalo.
- Because of the effect of cyclosporine and erythromycin on Livalo blood levels, cyclosporine should not be administered with Livalo and a dose of 1 mg daily should not be exceeded when Livalo is used in combination with erythromycin.
- When combined with Priftin (rifampin) the maximum recommended dose of Livalo is 2 mg daily.
- Grapefruit juice and Fenofibrate also increase blood levels of Livalo but to a lesser extent.
- Sporanox, Sporanox Injection, Sporanox Oral Solution (itraconazole) decreases blood levels of Livalo.
- Since other statins interact with the components of Kaletra Tablets, Kaletra Capsules (lopinavir and ritonavir), Livalo should not be used with this combination.
- Fibrates, Niaspan, Advicor, Niacor (niacin), and Lopid (gemfibrozil) are known to increase adverse effects of statins and should be used cautiously with Livalo.
REFERENCE: FDA.gov. Livalo (pitavastatin) Prescribing Information.
Tips to keep it under control.