Livalo (pitavastatin) to Lower Cholesterol (cont.)
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
In this Article
- What is Livalo (pitavastatin)?
- How is Livalo (pitavastatin) prescribed?
- With which drugs does Livalo (pitavastatin) interact?
- What about taking Livalo (pitavastatin) during pregnancy?
- What are the side effects of Livalo (pitavastatin)?
How is Livalo (pitavastatin) prescribed?
- The usual dose range of Livalo is 1-4 mg daily
administered at any time of the day without regard to meals.
- Therapy is usually initiated at 2 mg daily and
increased after 4 weeks up to a maximum dose of 4 mg daily.
- Doses greater than 4 mg daily are associated with
severe muscle toxicity.
- The recommended dose for individuals with moderate renal dysfunction or on dialysis is 1-2 mg daily.
With which drugs does Livalo (pitavastatin) interact?
- Sandimmune, Neoral, Restasis, Gengraf Capsules, Gengraf Oral Solution (cyclosporine), erythromycin,
Reyataz (atazanavir), Rifadin, Rifamate, Rifater, Priftin (rifampin), and
Lopid (gemfibrozil) significantly increase blood levels of Livalo.
- Because of the effect of cyclosporine or erythromycin
on Livalo blood levels, cyclosporine should not be administered with Livalo and
a dose of 1 mg daily should not be exceeded when Livalo is used in combination
- When combined with Priftin (rifampin) the maximum recommended
dose of Livalo is 2 mg daily.
- Grapefruit juice and Fenofibrate also increase blood
levels of Livalo but to a lesser extent.
- Sporanox, Sporanox Injection, Sporanox Oral Solution (itraconazole) decreases blood levels of Livalo.
- Since other statins interact with the combination of Kaletra Tablets,
Kaletra Capsules (lopinavir and ritonavir), Livalo should not be used with this combination.
- Fibrates, Niaspan, Advicor, Niacor (niacin), and Lopid (gemfibrozil) are known to increase adverse effects of statins and should be used cautiously with Livalo.
Reference: Livalo (pitavastatin) Prescribing Information, 2009
Tips to keep it under control.