HIV and AIDS: Treatments and Medications (cont.)
In this Article
- Entry Inhibitors (including Fusion Inhibitors) and CCR5 Co-receptor Antagonist
- HIV Integrase Strand Transfer Inhibitors
- Multi-Class Combination Drugs
- Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
- Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)
- Protease Inhibitors (PIs)
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
NRTIs block an enzyme of the HIV called reverse transcriptase that allows HIV to infect human cells, particularly CD4 T cells or lymphocytes. Reverse transcriptase converts HIV genetic material, which is RNA, into human genetic material, which is DNA. The human-like DNA of HIV then becomes part of the infected person's own cells, allowing the cell to produce RNA copies of the HIV that can then go on to attack other not yet infected cells. Thus, blocking reverse transcriptase prevents HIV from taking over (infecting) human cells.
| Brand Name | Generic Names | Manufacturer |
| Combivir | lamivudine and zidovudine | GlaxoSmithKline |
| Emtriva | emtricitabine, FTC | Gilead Sciences |
| Epivir | lamivudine, 3TC | GlaxoSmithKline |
| Epzicom | abacavir and lamivudine | GlaxoSmithKline |
| Hivid | zalcitabine, dideoxycytidine, ddC | Hoffmann-La Roche |
| Retrovir | zidovudine, azidothymidine, AZT, ZDV | GlaxoSmithKline |
| Trizivir | abacavir, zidovudine, and lamivudine | GlaxoSmithKline |
| Truvada | tenofovir disoproxil fumarate and emtricitabine | tenofovir disoproxil fumarate and emtricitabine |
| Videx EC | enteric coated didanosine, ddI EC | Bristol Myers-Squibb |
| Videx | didanosine, dideoxyinosine, ddI | Bristol Myers-Squibb |
| Viread | tenofovir disoproxil fumarate, TDF | Gilead |
| Zerit | stavudine, d4T | Bristol Myers-Squibb |
| Ziagen | abacavir sulfate, ABC | GlaxoSmithKline |
SOURCES:
The U.S. Food and Drug Administration
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