font size

Definition of Currarino syndrome

Currarino syndrome: Failure of formation of all or part of the sacrum (the lowest section of the spine).

Currarino syndrome is a condition characterized by the combination of:

  • Partial absence of the sacrum (the lowest portion of spine),
  • Anorectal (anal and rectal) abnormalities, and
  • An abnormal mass in front of the sacrum (due to a meningocoele or teratoma).

The malformations in Currarino syndrome are all in tissues that have their embryological origin in the tail bud and may reflect disturbances in its formation during early embryonic life. A mutation (change) in a gene called the HLXB9 homeobox gene has been identified as responsible for autosomal dominant Currarino syndrome, also known as hereditary sacral agenesis.

Source: MedTerms™ Medical Dictionary
http://www.medterms.com/script/main/art.asp?articlekey=12974
Last Editorial Review: 6/14/2012

Drug Medical Dictionary of Terms by Letter

Top RxList Drug News

Women's Health

Find out what women really need.

advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations