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Weight Loss Surgery Puts Diabetes Into Remission

Bariatric Procedures Beat Out Medication at Controlling Blood Sugar

By Charlene Laino
WebMD Health News

Reviewed By Brunilda Nazario, MD

March 26, 2012 (Chicago) -- Weight loss surgery beat out the best available medications at controlling blood sugar in overweight and moderately obese people with type 2 diabetes, researchers report.

People who underwent one of two stomach-reducing procedures were three to four times more likely to have their blood sugar drop to normal levels after one year of treatment compared with people who received intensive medical therapy alone.

Some people who had surgery got better so quickly that they were able to stop taking their diabetes medication before even leaving the hospital, says study head Philip Schauer, MD, director of the Bariatric and Metabolic Institute at the Cleveland Clinic.

They "were eventually weaned off all their diabetes medication -- as close to the definition of remission as you can get," Schauer tells WebMD.

"Bariatric [weight loss] surgery works and works well -- for both obesity and diabetes," Schauer says.

The findings were presented at the annual meeting of the American College of Cardiology and simultaneously published online by The New England Journal of Medicine.

Most People With Diabetes Overweight or Obese

About 80% of the 23 million American adults living with type 2 diabetes are overweight or obese.

High blood sugar is a major risk factor for a host of diabetes complications, including heart attack, amputation, kidney failure, and blindness.

In one recent study, 89% of people with type 2 diabetes who underwent gastric bypass surgery went into remission and 57% were still in remission after five years.

The new study, called STAMPEDE, involved 150 people -- two-thirds of whom were women -- with a body mass index (BMI) between 27 and 43. They were divided into three groups. Two groups received surgery: either gastric bypass, which surgically reduces the stomach size and reroutes food to bypass part of the small intestine; or sleeve gastrectomy, a procedure that surgically reduces the stomach by about 75%. Both procedures require about two or three days in a hospital and two to four weeks of recovery time.

The third group got intensive medical therapy for diabetes, which included various types of oral medications or injectables, including insulin.

Better Blood Sugar Control in Surgery Groups

At the start of the study, people had very high blood sugar, as measured by a test called hemoglobin A1c, or HbA1c. The average HA1c levels were 9.2% at the start of the study. An HbA1c level of 7% or lower is the traditional target for diabetes patients, but the study's goal was to reach a HbA1c level of 6% or less after one year.

Results showed that 42% of patients who underwent gastric bypass surgery achieved that goal, compared with 37% of patients who got the sleeve gastrectomy. Only 12% in the medication group reached that goal.

People who had surgery benefited in other ways, too. Their use of medications to lower blood pressure and cholesterol levels dropped, while use increased in people on intensive medical therapy. Not surprisingly, people getting surgery lost five times as much weight: about 55 to 64 pounds compared to 12 pounds in the medication group.

But surgery did have risks -- mainly bleeding, dehydration, and nausea. Fifteen of the 99 patients had side effects requiring hospitalization. No one died or had a life-threatening complication.

The study didn't compare costs, but surgery can run $20,000 to $30,000 and may not be covered by insurance, Schauer says. But medications can also add up. A person diagnosed at age 50 can expect to spend $172,000 on the condition -- that's equal to more than eight gastric bypass procedures, he says.

It's not year clear if lowering HbA1c levels to 6% or less translates to better heart health. "We would suspect it does, but it remains to be proven. More people have to be studied for longer periods of time," says Rick Nishimura, MD, a Mayo Clinic heart specialist and head of the ACC committee that chose which studies to highlight at the meeting.

People thinking about weight loss surgery should make sure to go to one of the approximate 500 hospitals that have been named "certified centers of excellence" by the American College of Surgeons or the American Society for Metabolic and Bariatric Surgery, Schauer says.

The study was funded in part by Ethicon Endo-Surgery Inc., a maker of bariatric surgery instruments. Schauer has consulted for the company.

SOURCES:

Schauer, P. New England Journal of Medicine, published online March 26, 2012.

American College of Cardiology's 61st Annual Scientific Session, Chicago, March 24-27, 2012.

Philip Schauer, MD,professor of surgery, Cleveland Clinic Lerner College of Medicine.

Rick Nishimura, MD, Mayo Clinic, department of cardiology, Rochester, Minn.

© 2012 WebMD, LLC. All rights reserved.



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