Definition of Y-linkage
Y-linkage: The presence of a gene on the Y chromosome. Y-linkage is analogous to X-linkage (the presence of a gene on the X chromosome) in that it says a gene is on one of the sex chromosomes.
It has often been said that little is known about Y-linkage. This is no longer true. As of the year 2012, about 3 dozen genes were known to be Y-linked including:
- ASMTY (which stands for acetyl serotonin methyltransferase),
- TSPY (testis-specific protein),
- IL3RAY (interleukin-3 receptor),
- SRY (sex-determining region),
- TDF (testis determining factor),
- ZFY (zinc finger protein), PRKY (protein kinase, Y-linked),
- AMGL (amelogenin),
- CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome),
- ANT3Y (adenine nucleotide translocator-3 on the Y),
- AZF2 (azoospermia factor 2),
- BPY2 (basic protein on the Y chromosome),
- AZF1 (azoospermia factor 1),
- DAZ (deleted in azoospermia),
- RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1),
- RBM2 (RNA binding motif protein 2) and
- UTY (ubiquitously transcribed TPR gene on Y chromosome).
Last Editorial Review: 9/20/2012
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