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Definition of Lamin A

Lamin A: Abbreviated LMNA. A gene on chromosome 1 that encodes a protein which is a key component of the membrane surrounding the cell nucleus.

Mutations in the LMNA gene are responsible for a number of genetic disorders including:

  • Progeria syndrome,
  • Emery-Dreifuss muscular dystrophy type 2,
  • Limb girdle muscular dystrophy type 1B,
  • Charcot-Marie-Tooth disorder type 2B1,
  • The Dunnigan type of familial partial lipodystrophy,
  • Mandibuloacral dysplasia and
  • A familial form of dilated cardiomyopathy.

Source: MedTerms™ Medical Dictionary
http://www.medterms.com/script/main/art.asp?articlekey=23121
Last Editorial Review: 6/14/2012

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