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Definition of Prodrug

Prodrug: A precursor (forerunner) of a drug. A prodrug must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent. For example, sulfasalazine is a prodrug. It is not active in its ingested form. It has to be broken down by bacteria in the colon into two products -- 5-aminosalicylic acid (5ASA) and sulfapyridine -- before becoming active as a drug.

Source: MedTerms™ Medical Dictionary
http://www.medterms.com/script/main/art.asp?articlekey=23992
Last Editorial Review: 6/14/2012

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