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Definition of Downregulation

Downregulation: An decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or another agent. For example, insulin receptors may be downregulated in type 2 diabetes.

Source: MedTerms™ Medical Dictionary
http://www.medterms.com/script/main/art.asp?articlekey=24471
Last Editorial Review: 9/20/2012

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