font size

Definition of Parkinson disease gene

Parkinson disease gene: A gene involved in the causation of Parkinson disease. There are a number of different autosomal dominant and recessive forms of Parkinson disease.

They are called PARK1, PARK2, and so on:

  • PARK1 is an autosomal dominant trait and is due to mutation in the alpha-synuclein gene (SNCA) on chromosome 4q21;
  • PARK2 is an autosomal recessive trait and is due to mutation in the gene encoding parkin on chromosome 6q25.2-q27;
  • PARK3 is an autosomal dominant trait and is due to a gene on chromosome 2p13;
  • PARK4 is an autosomal dominant trait and is due to a gene on chromosome 4p15;
  • PARK5 is an autosomal dominant trait and is due to mutation in the UCHL1 gene on chromosome 4p14;
  • PARK6 is an autosomal recessive trait and is due to mutation in a gene on chromosome 1p distinct from DJ1;
  • PARK7 is an autosomal recessive trait and is due to mutation in the DJ1 gene on 1p36;
  • PARK8 is an autosomal dominant trait and is due to a gene on chromosome 12p11.2-q13.1;
  • PARK9 is an autosomal recessive trait and is due to a gene on chromosome 1p36;
  • PARK10 is an autosomal dominant trait and is due to a gene on chromosome 1p;
  • PARK11 is an autosomal dominant trait and is due to a gene on chromosome 2q.

People in an Iowa family affected with an early-onset autosomal dominant form of Parkinson disease have a triplication of the alpha-synuclein gene (SNCA) on chromosome 4q21. This may be another genetic route to PARK1.

Source: MedTerms™ Medical Dictionary
http://www.medterms.com/script/main/art.asp?articlekey=25045
Last Editorial Review: 6/14/2012

Drug Medical Dictionary of Terms by Letter

Top RxList Drug News

WebMD Daily

Get breaking medical news.

advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations