font size

Definition of MEF2A

MEF2A: A transcription factor that participates in vascular development. MEF2A is a member of the myocyte enhancer factor-2 (MEF2) family of transcription factors. Messenger RNA (mRNA) from MEF2A has been detected in blood vessels during early embryogenesis. The gene for MEF2A is located on chromosome 15q26.

A heritable deletion within the MEF2A gene that results in the loss of 7 amino acids appears responsible for an autosomal dominant form of coronary artery disease. The deletion alters the cellular distribution of the MEF2A protein and may prevent its function as a vascular transcription factor. It remains to be seen if the MEF2A pathway plays a role in the common form of coronary artery disease resulting from atherosclerosis.

MEF2A is also known as MADS box transcription enhancer factor 2, polypeptide A.

Source: MedTerms™ Medical Dictionary
http://www.medterms.com/script/main/art.asp?articlekey=25496
Last Editorial Review: 6/14/2012

Drug Medical Dictionary of Terms by Letter

Top RxList Drug News

Women's Health

Find out what women really need.

advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations