font size

Definition of TPH2

TPH2: Tryptophan hydroxylase 2, also known as neuronal tryptophan hydroxylase (NTPH), the key rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous activities in the central nervous system, and it also has other functions including the maintenance of vascular tone and gut motility. The TPH2 gene is on chromosome 12.

A functional genetic polymorphism (variation) in the TPH2 gene results in the substitution of a single amino acid in the TPH2 protein. This minute change in TPH2 leads to decreased brain serotonin levels and provides direct evidence for a fundamental role of TPH2 in the production of serotonin in the brain. Dysregulation of brain serotonin contributes to some psychiatric disorders.

Source: MedTerms™ Medical Dictionary
http://www.medterms.com/script/main/art.asp?articlekey=33980
Last Editorial Review: 6/14/2012

Drug Medical Dictionary of Terms by Letter

Top RxList Drug News

advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations