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Definition of Gain-of-function mutation

Gain-of-function mutation: A mutation that confers new or enhanced activity on a protein. Loss-of-function mutations, which are more common, result in reduced or abolished protein function.

Source: MedTerms™ Medical Dictionary
http://www.medicinenet.com/script/main/art.asp?articlekey=39613
Last Editorial Review: 6/14/2012

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