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Definition of Meiotic nondisjunction

Meiotic nondisjunction: Failure of two members of a chromosome pair to separate from one another during meiosis, causing both chromosomes to go to a single daughter cell. Meiotic nondisjunction is responsible for the extra chromosome 21 in trisomy 21 (Down syndrome) and for extra and missing chromosomes that cause other birth defects and many miscarriages.

Source: MedTerms™ Medical Dictionary
http://www.medicinenet.com/script/main/art.asp?articlekey=4337
Last Editorial Review: 3/19/2012

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