Definition of Y-linked inheritance
Y-linked inheritance: Inheritance of genes on the Y chromosome. Since only males normally have a Y chromosome, Y-linked genes can only be transmitted from father to son.
Y-linked inheritance is also called holandric inheritance.
A number of genes were are known to be Y-linked including:
- ASMTY (which stands for acetylserotonin methyltransferase),
- TSPY (testis-specific protein),
- IL3RAY (interleukin-3 receptor),
- SRY (sex-determining region),
- TDF (testis determining factor),
- ZFY (zinc finger protein), PRKY (protein kinase, Y-linked),
- AMGL (amelogenin),
- CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome),
- ANT3Y (adenine nucleotide translocator-3 on the Y),
- AZF2 (azoospermia factor 2),
- BPY2 (basic protein on the Y chromosome),
- AZF1 (azoospermia factor 1),
- DAZ (deleted in azoospermia),
- RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1),
- RBM2 (RNA binding motif protein 2) and
- UTY (ubiquitously transcribed TPR gene on Y chromosome).
Last Editorial Review: 10/30/2013