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Definition of Inversion, pericentric chromosome

Inversion, pericentric chromosome: A basic type of chromosome rearrangement in which a segment that includes the centromere (and so is pericentric) has been snipped out of a chromosome, turned through 180 degrees (inverted), and inserted back into its original location in chromosome. The feature that makes it pericentric is that both breaks are on either side of the centromere (the point at which the chromosome attaches to the spindle).

Any chromosome inversion can be inherited and have come from one of the parents to a child. Or the inversion can appear for the first time in a child.

An inversion can be "balanced", meaning that it has all the genes present in the normal uninverted chromosome. Or an inversion can be "unbalanced", meaning that genes been have deleted (lost) or duplicated.

A balanced inversion in a child causes no problems. An unbalanced inversion is abnormal and is often associated with problems such as development delay (and later, mental retardation) (substitute intellectual disability anywhere that mental retardation appears in glossary) and multiple congenital anomalies (birth defects).

Inversions can also be acquired in a body cell (a somatic cell) and be a step involving that cell in a precancerous and cancerous process.

Source: MedTerms™ Medical Dictionary
http://www.medicinenet.com/script/main/art.asp?articlekey=8192
Last Editorial Review: 9/20/2012

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