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COX-2 Inhibitors (cont.)
Annette (Gbemudu) Ogbru, PharmD, MBA
Dr. Gbemudu received her B.S. in Biochemistry from Nova Southeastern University, her PharmD degree from University of Maryland, and MBA degree from University of Baltimore. She completed a one year post-doctoral fellowship with Rutgers University and Bristol Myers Squibb.
Jay W. Marks, MD
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
In this Article
- What are COX-2 inhibitors, and how do they work?
- For what conditions are COX-2 inhibitors used?
- Are there any differences among the different types of COX-2 inhibitors?
- What are the side effects of COX-2 inhibitors?
- With which drugs do COX-2 inhibitors interact?
- Which COX-2 inhibitors are available?
For what conditions are COX-2 inhibitors used?
COX-2 inhibitors are used for treating conditions that cause inflammation, mild to moderate pain, and fever. Examples include:
Unlike aspirin, also an NSAID, they are not effective for preventing strokes and heart attacks in individuals at high risk for such events.
Are there any differences among the different types of COX-2 inhibitors?
Celecoxib is the only COX-2 inhibitor currently available in the United States. Rofecoxib (Vioxx) and valdecoxib (Bextra) are no longer available because they increased the risk of heart attacks and strokes with long term use. Rofecoxib was discontinued in 2004 and valdecoxib was discontinued in 2005.
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