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COX-2 Inhibitors (cont.)
Annette (Gbemudu) Ogbru, PharmD, MBA
Dr. Gbemudu received her B.S. in Biochemistry from Nova Southeastern University, her PharmD degree from University of Maryland, and MBA degree from University of Baltimore. She completed a one year post-doctoral fellowship with Rutgers University and Bristol Myers Squibb.
Jay W. Marks, MD
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
In this Article
- What are COX-2 inhibitors, and how do they work?
- For what conditions are COX-2 inhibitors used?
- Are there any differences among the different types of COX-2 inhibitors?
- What are the side effects of COX-2 inhibitors?
- With which drugs do COX-2 inhibitors interact?
- Which COX-2 inhibitors are available?
With which drugs do COX-2 inhibitors interact?
Concomitant use of celecoxib with aspirin or other NSAIDs [for example, ibuprofen, naproxen (Naprosyn, Naprelan), etc.) may increase the occurrence of stomach and intestinal ulcers. It may be used with low dose aspirin.
Alcohol consumption increases the risk of developing stomach ulcers when taking NSAIDs; this may also apply to celecoxib.
Fluconazole (Diflucan) increases the concentration of celecoxib (Celebrex) in the body by inhibiting the elimination of celecoxib in the liver.
Celecoxib (Celebrex) increases the concentration of lithium (Eskalith) in the blood by 17% and may increase the blood thinning effect of warfarin (Coumadin).
Which COX-2 inhibitors are available?
Celecoxib (Celebrex) is the only COX-2 inhibitor available in the United States.
Last Editorial Review: 12/4/2008
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