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COX-2 Inhibitors (cont.)

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Medical Editor:

With which drugs do COX-2 inhibitors interact?

Concomitant use of celecoxib with aspirin or other NSAIDs [for example, ibuprofen, naproxen (Naprosyn, Naprelan), etc.) may increase the occurrence of stomach and intestinal ulcers. It may be used with low dose aspirin.

Alcohol consumption increases the risk of developing stomach ulcers when taking NSAIDs; this may also apply to celecoxib.

Fluconazole (Diflucan) increases the concentration of celecoxib (Celebrex) in the body by inhibiting the elimination of celecoxib in the liver.

Celecoxib (Celebrex) increases the concentration of lithium (Eskalith) in the blood by 17% and may increase the blood thinning effect of warfarin (Coumadin).

Which COX-2 inhibitors are available?

Celecoxib (Celebrex) is the only COX-2 inhibitor available in the United States.


Last Editorial Review: 12/4/2008



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