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Tricyclic Antidepressants (TCAs) (cont.)

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With which drugs do tricyclic antidepressants interact?

Tricyclic antidepressants should not be used with monoamine oxidase inhibiting drugs [for example, tranylcypromine (Parnate)]. High fever, convulsions, and even death can occur from such combinations.

Epinephrine (Primatene, Adrenalin, Ana-Kit, EpiPen, Marcaine) should not be used with tricyclic antidepressants, since together they can cause severe high blood pressure.

Alcohol blocks the antidepressant action of tricyclic antidepressants but increases its sedative effect.

Cimetidine (Tagamet) can increase blood levels and side effects of tricyclic antidepressants.

Combining tricyclic antidepressants with drugs that block acetylcholine can stop bowel movements and paralyze the intestine (paralytic ileus). Dangerous elevations in blood pressure may occur if TCA are combined with clonidine (Catapres, Catapres-TTS).



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