Symptoms of menopause curtailed, such as hot flashes, night sweats, dryness, etc. as others have noted. Mentally, emotionally = greatest impact on quality of life. Increased my energy, mental state, ability to concentrate and focus, giving me more energy, too. A big difference. Highly recommend. No downside for me. I am 54 and have taken 3 years.

After watching Oprah and Suzanne Sommers discuss bioidentical HRT, I tried to get into my Ob/gyn for a consultation -- I'd been experiencing anxiety for 2 two years (!!), but tried to gut it out thinking I could get through using soy, black cohash, etc. I finally couldn't stand it anymore because I wasn't getting any sleep at night either. After research decided not to go the compounding pharmacy route, and was put on activella. After 3 days woke up and didn't have any anxiety! OMG I had forgotten what "normal" felt like! No more migraines either -- after several years! Jeez, why didn't my female doc tell me about this earlier!! Just upset that my quality of life suffered for prob 5 years, but I JUST DIDN'T KNOW IT WAS MENOPAUSAL ONSET. I love these hormones!!

I have been very leery about taking a HR, but couldn't deal with waking up 6x per night and the emotional highs and lows. Honestly after the 1st night I felt a difference. After 3-4 nights no more hot flashes (day or night). My breast are tender, and there is slight vaginal discomfort, but the trade off is huge. Just a little nervous enough to keep researching possible side effects on a regular basis

It's been four years now on a low dosage of Activella. Within one week of starting all symptoms stopped- hot flashes ; crying; irritability and the constant headaches. I was 45 when I started.Tried to go off on two occasions.....all symptoms came back within 2 weeks.

Worked for me within a week. Would give up a meal before giving up Activella. No more hot flashes, night sweats and irritability. I sleep much better.

Have been on Activella for about 9 years now and love it. No side effects. No hot flashes, although I stopped taking it for a month after I turned 65 (thought I wouldn't need it any more), but started having hot flashes again, so . . . back on it. Would never want to go back to having those hot flashes again! Heart's good, weight's fine, no bloating, sex drive is good (i'm 66 now!).

Felt great the first 3 weeks, hot flashes went away, slept better, sex drive up, and lots of vaginal lubrication. Got a severe yeast infection, then the awful PMS came back. Hadn't had a period in 6 months, then bled for 11 days and felt horrible. No energy, abdominal and back pain, bloating and cramping, depression and crying. Then I noticed the main reason I will no longer use this drug, my hair is falling out on top of my head. That is also one of the side effects. Now I just have to figure out if I can just stop taking it or should I wean myself off?

I had some breakthrough bleeding with 1 whole pill per day, but have done well with 1/2 tab per day. No hot flashes and no vaginal dryness problems