This medication reduced the platlet count, and was easy to swallow. However, everything I have read and the experience of my husband taking this drug, I am surprised it's still on the market. My husband had a massive stroke. When life flighted to UC Davis the Hem. doctor told me he should have never been placed on this drug. It was probably the cause of his bleed. When I looked it up on the internet, it showed that during an Agrylin study of 89 people, 57% of the people dropped out due to serious complications. This was on WebMd dated July 5, 2005. In fact, it stated that their findings were so astonishing that they halted their study to publish the results. I continued my search and found that several doctors have found that Agrylin is not a suitable choice for ET. I continue to research it and continue to find more and more. I have contacted the FDA and have received no response other than they would check into it. Published: March 16, 2008 ::

so far doing ok on medication Published: September 23, 2007 ::

This medication was prescribed for the treatment of thrombocytosis. It replaced the drug hydroxyurea when that drug began to decline in effectiveness. After taking Agrylin for about two years, I was diagnosed with hypertension. Hemotologist treating me did not attribute the high blood pressure to the drug but after getting a second opinion was told that it does in fact cause hypertension. When I switched back to hydrea, my high blood pressure went back to normal. In addition to the hypertension, I had irregular heart beats, severe headaches, and swelling of my ankles. Feel much better since I was taken off and returned to hydrea which began to work again after being off for two years. Published: February 19, 2008 ::

Use of Agrylin has resulted in acceptably lowered platelet counts over several years for essential thrombocytosis. Published: January 17, 2008 ::

Have used Agrylin for ET for nearly 10 years. Do have the usual dosage adjustments now and then, but it has been effective in controlling platelet levels. HOWEVER, within past couple of years, issues have arisen with elevated white cells, chronic severe anemia and poor lab results re: calcium, etc. Is it related to long term use of Agrylin? Is it just a progression of the genetic mutations? Who knows? Sadly, no one seems to be interested in researching this rare phenomenon. Published: February 06, 2009 ::

So far agrylin has helped my platelets go down. When I went on them my platelets were over 900,000, but in two weeks they were down to 618,000. I had no side effects. Published: May 29, 2009 ::

effective,but rapid heartbeat sometie Published: May 22, 2009 ::

I have been on this med. since 2005. It does a good job of keeping my platlet count down, but I have the side effect of rapid heart beat. I have been to a cardiologist who has said my heart is fine and not damaged. I also feel extremely tired even though my lab results do not show abnormal results. Lately my gall bladder/liver area has been giving me pain, which I am about to have checked out. I don't know if these are connected to this medication or not. Published: February 27, 2009 ::