My IBS condition severely impacted my life. I was unable to participate in activities because I never knew when a bout may occur. They were severe and occurred often. Since taking the medication i am able to enjoy life again and I feel great too. I know that the medication has it's risk but in my situation the benefits have far outweighed the risk and I am not even taking the full minimal dose of the medication! Published: September 19, 2007 ::

I do not know what I would do without this medication. I have severe diarrhea. This pill makes me normal. Imodium was good for me, but it did not form the stool. This pill forms the stool. I have been on this medication for several years now. I hope it never stops working for me. Published: January 03, 2008 ::

I agree that it is a wonder drug. It isn't perfect but it is the best/only drug out there that remotely works. It allows me to have a life and career. Published: December 12, 2007 ::

While not 100% better - taking Lotronex allows me to have a better quality of life without constantly searching for a bathroom while away from home. Works much better than Bentyl, Lomotil, Immodium. No side effects of dry mouth or drowsiness. Published: October 04, 2007 ::

My life was miserable before taking Lotronex and was faced with having to quit my job because I travel often. I was constantly seeking out bathroom locations and an embarassing situation in a cab ride just about made me hand in my resignation. This drug has without a doubt saved my life and I have no fear of traveling or meeting clients for meals. I don't take it every day, only when I recognize the symptoms of IBS and I immediately take a pill. Just knowing that the episode will pass I am immediately relaxed and ready to carry on with my day. I thank God that my physician put me on this miracle drug. He gave me back my life. Published: February 27, 2008 ::

it works better than anything I have tried,am curious if other males are using it since it has only been tested on women Published: October 25, 2007 ::

I have been taking Lotronex ever since it came back onthe market - I think it was 2005. I haqd also aken it before it waqs removed. I call it a miracle drug for me.I would like to know if there have been any reports of it losing effectiveness after 5 years which seems to be happening to me. I am aking two 0.5 maybe I need to go back to 2 of 1.0. Published: October 21, 2007 ::

Lotronex has made a tremendous diference in my quality of life. I teach middle schoolers, and before this drug I was looking for another career. I take the max dose, 2 1mg tabs per day, and still have some urgency, some loose stools, but no more accidents, leakage or explosive diarrhea. I wish a higher dose was available to me, but as long as this dosage keeps working like this, I'll be happy. Published: September 08, 2008 ::

I'm taking(1) .5 mg twice a day, the first day was immediate relief. Day 2 no pain but upset stomach. Day 3 still no pain bowel movements are less but still urgent when it's time. I possibly need an increase in stregth. But after 20 years of nothing else working. . . I don't know how to act/sk Published: May 09, 2008 ::

I've read the reviews regarding this drug, Lotronex. I too, have suffered with IBS/D for several years & for the past 5 years have been taking 1 mg p/day. While I am most grateful for having my life back (working, shopping, socializing, etc.), I have experienced an increase in the cost of the medication for the past 13 months. I live in IL & now pay $545.00 per month for 30 pills (Initially, cost was $180.00). I do know that Glaxco-Smith Kline SOLD this drug to Prometheus Laboratories, San Diego, CA approximately 1/08. Whether it is new marking stratgies by Prometheus to off-set their cost of purchasing/manufacturing this drug, I feel $545.00 per month is completely UNREASONABLE both to the patient as well as my medical insurance coverage. While I am fortunate, at the moment, to have a prescription plan which pays for 85% of the cost, this claim, per month is calculated toward my overall lifetime maximum for my major medical coverage. I feel that there is a such a small percentage of patients that fit the criteria in need of this medication we have no option, currently, other than to pay this EXCESSIVE price. I look forward to the day when there will be a GENERIC form of this drug (as far as I know there is none). I will be discussing this issue with my GI doctor in the very near future. I wish everyone with this disorder continued days without our every thought being..."WHERE IS THE BATHROOM". Published: February 08, 2009 ::