Here is a collection of user reviews for the medication Periostat sorted by most helpful. 
The following Patient Discussions have not been medically reviewed. See additional information.
Prescribed by dentist after scaling and root planing. Had to stop taking it because of blood in stools. Also had to stop other medications (simvastatin, baby aspirin and Chantix) until condition clears, and be subjected to a sigmoidoscopy. Published: October 24, 2008 ::
I did not need gum surgery after taking Periostat but - according to the mfg- I was one of 4 people who's intestines were destroyed by this drug. I came down with to pseudomembranous colitis and I have suffered from spasms and non-stop diarrhea for 5 or more years now. It's awful and I am miserable. I couldn't sue because they did not know anyone would react to Periostat like this. I went thru so many doctor bills, hospital bills, etc and the mfg paid nothing. My doctor said I had the worse case of pseudomembranous colitis that he had ever seen in 20 years. He told me to warn everyone NOT to use it and for me to tell all my doctors what happened to me. 1 hour of oral surgery would have been easier than a life time of diarrhea. Published: January 02, 2009 ::
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Had to stop because it caused Thrombocytopenia (low blood platelets). Tell your doctor or have your dentist tell your doctor you are taking this medication! Published: June 19, 2008 ::