Here is a collection of user reviews for the medication Prefest sorted by most helpful. 
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Used Prefest for 3 months and decided to discontinue use because of "cons"- Cons- experienced spotting and breast tenderness, some leg cramping (but only for a week). Symptoms probably caused by too much estrogen in "one size fits all" pill. Pros- no more hot flashes, sleeping better, mood improved greatly. Would have liked to continue using Prefest because of the "pros", but the "cons" scared me a little. Also, using a transdermal method is reported to be a bit safer. Will look to try something else in a lower dose. Published: May 17, 2009 ::