I was diagnosed with RA about 8 yrs ago and have been in remission for about 5 years. Had been on Enbrel until fall 2008 (flu shot?) when flare prompted dr to put me on Humira. Started having severe monthly flares after receiving seasonal flu shot Oct 2009 (now banned from flu shots!). Had 1st Rituxan infusion mid-Jan 2010 and 2nd 2 wks later as directed. 1st dose stopped RA from traveling within my body several times per day, and helped lower body immensely just after 1 day. Upper body joints remained inflamed and painful. 1 day after 2nd dose left my joints virtually pain-free; range of motion still limited though. Side effects remain of nausea, sweats, chills, but I'll take them over the joint pain anyday as they are temporary. Both times I was prepped with tylenol, benedryl, and an steroid so I no adverse reaction during the infusions. Definitely a good thing so far!