I've been diagnosed with RA for over 10 years now and have been on and off of methotrexate a couple of times. Currently, I've been on it for 1.5 years and am having moderate success with it. However, it does make me tired and nauseated on the day that I take it. And it hasn't completely made me pain free or fatigue free from the RA. However, because of other medical conditions it is really my only option. Published: June 18, 2009 ::

I have used mxt for 2 years. Other than the fear of all the side effects, mxt has worked well for me along with Enbrel. I currently haven't had any side effects. I'm taking (8)2.5 mg once a week. The last two months I've tried to cut down to 6, because I was feeling so well and didn't like the possible side effects. I feel like my pain has increased and my mobility has decreased, so with the Dr's approval will probably work back up to 8. Published: July 20, 2009 ::

I was diagnosed with RA 2 years ago. I tried methotrexate without much relief for 8-9 months. They dosed me with a wide variety of NSAIDs along with it, but none of them helped at all. A new dr. put me on Arava, with the metho & my liver enzymes went sky high. They are still not back to normal after nearly a year with no meds at all. I just got scared away from taking anything, but wrist joint damage has begun. So, I started plaquenil, and I am trying milk thistle and staying away from all alcohol for the time being. We shall see, not much relief so far, just digestive issues, increased hot flashes and mid-afternoon into evening fatigue that wrecks my life. I have Sjoerens & Reynauds also. I had wheezing yesterday – haven’t had that since on metho. But, of course the Drs. say it is not associated. Published: October 24, 2008 ::

I have been taking methotrexate now for almost a year and see no change in my current psoriasis areas and i have noticed that i am still getting new break outs. Published: October 03, 2008 ::