Extremely tired first few days after each monthly infusion. Followed by significant improvement of most aspects of my MS. Have had MS for 23 years, and Tysabri has proven to be the most effective treatment I have received thus far. Published: October 18, 2007 ::

I am very happy with Tysabri, since starting it both myself and my husband has noticed a change in my life. How I feel both cognitive and physical. Published: September 26, 2007 ::

Was on rebif (2-3 relapses per yr), then Copaxone(7 relapes in 8 mo). Didn't know about 6 mth period of waiting for Copaxone to kick in. Put on Tysabri, 0 relapes in 10 months so far. Works immediately, safe to use. Other than regular numbness I've always had, I feel the same I did before my MS diagnosis. Published: November 29, 2007 ::

After 2yrs I developed antibodies against Rebif. My doctor immediately started me on Tysabri. I'm on my 4th month and so far so good. My symptoms have so far remained in remission...I'm happy. The way I figure- I'm going to do whatever I can to take control of this disease. Published: November 02, 2007 ::

I have been on Tysabri for 15 months. I get no side effects( as I did for 8 years on avonex) I had been hospitilized two times in three months prior to my infusions. I am not dancing in the street but I have not gotten worse. Something avonex could not do for me. Published: November 14, 2007 ::

on my 6th iv have had depression, panicky feeling, joint pain, head pain, i am doing better than on avonex hoping these problems will smooth out just trying to deal w/ms thorn Published: October 10, 2007 ::

I was diagnosed w/MS 21 years ago-spent 13 yrs. doing every-other-day self-injections of Beta Seron, which worked well for that time, but then developed anti-bodies and went into a severe downward spiral in all aspects of this disease. Started Tysabri 14 months ago and it is working well for me. I have some very ugly side effects, but I can deal with them better than the dibilitating effects of MS. I have found that keeping a daily journal has been extremely beneficial-helpful for me and for my doc and infusion RN. I started my journal the day of my first infusion and have kept it going since. It has enabled me to prepare for the side effects that I know are coming - extreme fatigue and achy joints day after infusion for 2-3 days; noticable spike in energy level by day 4; yeast infection 7 days post infusion; sleeplessness days 10-12; shingles across both hips and up tailbone day 3. These things are annoying, but by knowing when to expect them, I deal with it, and my over all health has been really good, and my energy level is almost what it was when I was disagnosed 21 years ago!! Published: March 12, 2008 ::

This treatment has been very expensive for my family, our insurance is a coin-insurance plan so after the insurance company pays 1,840.00.00 each month for the Tysabri, we pay an additional $460.00 plus another $174.00 per month for the infusion cost. I feel that the drug company should except what insurance companies pay so their victims can stay on their drugs that are helping them. Tysabri,YES is a good drug for multiple sclerosis but it should be made affordable for everyone to have the opportunity to try. The drug company tells you they have many assistance programs however it turns out that if you have a dime in your pocket there is no assistance for you! I have been on Tysabri for 14 months and I have not had a relapse in that time. I just want to say that PRIOR to going on Tysabri check your insurance information because this drug is one that you should stay on once you start providing you have no adverse reactions. Published: January 30, 2008 ::

Diagnosed in 2004. Scheduled to start Tysabri when it was withdrawn from market. Began on Copaxone with no results. Relapses every three months. Started Tysabri when I was able to find a neuro who would prescribe after it's return to market. I had an MRI before first infusion. Start delayed a month so I could do steroids for increased enhancing lesions and relapse. Began Tysabri and have had 22 infusions. MRI at 6 months showed no new lesions, no enhancing lesions and large lesions previously seen have reduced or are gone. MRI at 18 months showed further decline in number and size of lesions. No new lesions, no enhancing lesions. Quality of life is way up! Spasticity,stiffness and fatigue way down! Vision is back to pre-diagnosis level! No relapses since I started after cycling through relapses every three months before Tysabri. If it wasn't for the remaining spasticity,stiffness and fatigue I would swear I was "normal" If Tysabri hadn't been withdrawn from market I don't believe I would have the spasticity, stiffness and fatigue that I have now. I can live with those problems and treat them with baclofen and provigil, but the dose is half of what I used before Tysabri. I still hold hope that they will reduce further! Published: December 30, 2008 ::